Effects of antidepressants with different modes of action on early life stages of fish and amphibians

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000171" target="_blank" >RIV/00027162:_____/19:N0000171 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16270/19:43877479
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0269749119304257?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0269749119304257?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.envpol.2019.112999" target="_blank" >10.1016/j.envpol.2019.112999</a>

Result language
angličtina
Original language name
Effects of antidepressants with different modes of action on early life stages of fish and amphibians
Original language description
Drugs are excreted from the human body as both original substances and as metabolites and enter aquatic environment through waste water. The aim of this study was to widen the current knowledge considering the effects of waterborne antidepressants with different modes of action of amitriptyline, venlafaxine, sertraline on embryos of non-target aquatic biota in fish (represented by Danio rerio) and amphibians (represented by Xenopus tropicalis). The tested concentrations were 0.3; 3; 30; 300 and 3000 mg/L in case of amitriptyline and venlafaxine and 0.1; 1; 10; 100 and 1000 mg/L for sertraline. Test on zebrafish embryos was carried out until 144 h post fertilization, while test on Xenopus embryos was terminated after 48 h. Lethal and sublethal effects as well as swimming alterations were observed at higher tested concentrations that are not present in the environment. In contrast, mRNA expression of genes related to heart, eye, brain and bone development (nkx2.5, otx 2, bmp4 and pax 6) seems to be impacted also at environmentally relevant concentrations. In a wider context, this study reveals several indications on the ability of antidepressants to affect non target animals occupying environments which may be contaminated by such compounds.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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