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The effect of the antidepressant venlafaxine on gene expression of biotransformation enzymes in zebrafish (Danio rerio) embryos

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000367" target="_blank" >RIV/00027162:_____/19:N0000367 - isvavai.cz</a>

  • Alternative codes found

    RIV/00027162:_____/20:N0000001 RIV/62157124:16270/20:43878827

  • Result on the web

    <a href="https://link.springer.com/article/10.1007%2Fs11356-019-06726-2" target="_blank" >https://link.springer.com/article/10.1007%2Fs11356-019-06726-2</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s11356-019-06726-2" target="_blank" >10.1007/s11356-019-06726-2</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The effect of the antidepressant venlafaxine on gene expression of biotransformation enzymes in zebrafish (Danio rerio) embryos

  • Original language description

    The effect of venlafaxine, a pharmaceutical commonly found in aquatic environment, was analyzed on non-target organism, Danio rerio (Hamilton, 1822). D. rerio embryos were treated by two different concentrations of venlafaxine: either concentration relevant in aquatic environment (0.3 mu g/L) or concentration that was two orders of magnitude higher (30 mu g/L) for the evaluation of dose-dependent effect. Time-dependent effect was rated at 24, 96, and 144 h post-fertilization (hpf). For gene expression, genes representing one of the phases of xenobiotic biotransformation (0 to III) were selected. The results of this study showed that the effect of venlafaxine on the zebrafish embryos is the most evident at hatching (96 hpf). At this time, the results showed a downregulation of gene expression in each phase of biotransformation and in both tested concentrations. In contrast, an upregulation of most of the genes was observed 144 hpf for both tested venlafaxine concentrations. The study shows that venlafaxine can affect the gene expression of biotransformation enzymes in D. rerio embryos even in the environmentally relevant concentration and thus disrupt the process of biotransformation. Moreover, the pxr regulation of genes seems to be disrupted after venlafaxine exposure in dose- and time-dependent manner.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    40301 - Veterinary science

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Environmental Science and Pollution Research

  • ISSN

    0944-1344

  • e-ISSN

    1614-7499

  • Volume of the periodical

    27

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    11

  • Pages from-to

    1686-1696

  • UT code for WoS article

    000497830900002

  • EID of the result in the Scopus database

    2-s2.0-85075424342