Gene Expression and Immunological Response in Mice Exposed to ZnO Nanoparticles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000247" target="_blank" >RIV/00027162:_____/19:N0000247 - isvavai.cz</a>
Alternative codes found
RIV/68081715:_____/18:00499201 RIV/68378041:_____/18:00499201 RIV/67985904:_____/18:00499201 RIV/61989100:27200/18:10242335
Result on the web
<a href="https://asep.lib.cas.cz/arl-cav/cs/detail-cav_un_epca-0499201-GENE-EXPRESSION-AND-IMMUNOLOGICAL-RESPONSE-IN-MICE-EXPOSED-TO-ZnO-NANOPARTICLES/" target="_blank" >https://asep.lib.cas.cz/arl-cav/cs/detail-cav_un_epca-0499201-GENE-EXPRESSION-AND-IMMUNOLOGICAL-RESPONSE-IN-MICE-EXPOSED-TO-ZnO-NANOPARTICLES/</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Gene Expression and Immunological Response in Mice Exposed to ZnO Nanoparticles
Original language description
We analyzed gene expression changes in the lungs and the immunological response in splenocytes of mice exposed by inhalation of ZnO nanoparticles (NP). Adult female ICR mice were treated for three days and three months, respectively. Analysis of differential expression in genes involved in oxidative stress was conducted using quantitative RT-PCR. The potential immunotoxic and immunomodulatory effects of ZnO NP were analyzed by phenotyping and cytokine production by splenocytes after three months exposure. Three days exposure resulted in down-regulation of GCLC, GSR, HMOX-1, NQO-1, NF-kB2, PTGS2 and TXNRD1 mRNA expression; three months exposure increased the expression of these genes. Three months exposure caused a significant decrease in the percentage of granulocytes in the spleen cells, and affected the production of IL-10 and IL-6 by lipopolysaccharide-stimulated leukocytes. In summary, our study revealed changes in the expression of genes involved in the oxidative stress response following acute ZnO NP exposure. Subchronic ZnO NP exposure induced immunomodulatory effects in the spleen.
Czech name
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Czech description
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Project
<a href="/en/project/GBP503%2F12%2FG147" target="_blank" >GBP503/12/G147: Centre for studies on toxicity of nanoparticles</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
9th International Conference on Nanomaterials - Research and Application (NANOCON 2017)
ISBN
978-80-87294-81-9
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
650-655
Publisher name
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Place of publication
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Event location
Brno
Event date
Oct 18, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000452823300107

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