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Nanofibers in mucosal drug and vaccine delivery

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F20%3AN0000008" target="_blank" >RIV/00027162:_____/20:N0000008 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.intechopen.com/books/nanomaterials-toxicity-human-health-and-environment/nanofibers-in-mucosal-drug-and-vaccine-delivery" target="_blank" >https://www.intechopen.com/books/nanomaterials-toxicity-human-health-and-environment/nanofibers-in-mucosal-drug-and-vaccine-delivery</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5772/intechopen.82279" target="_blank" >10.5772/intechopen.82279</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Nanofibers in mucosal drug and vaccine delivery

  • Original language description

    Successful mucosal administration and delivery of drugs still pose a great challenge. However, the possibility to deliver not only small drug molecules, but also macromolecular drugs and nanoparticles via mucosal surfaces represents a great opportunity. Rapid onset of drug action, avoidance of first-pass metabolism, and high immunocompetence of mucosa are some of the important features for mucosal drug and vaccine delivery. The use of mucoadhesive drug delivery systems, systems with fast-dissolving properties, and nanomaterials with mucus penetration properties are examples of successful strategies to achieve effective mucosal drug and vaccine delivery. Non-keratinised mucosa of the oral cavity, the nasal and vaginal mucosa represent favourable sites of drug administration. Polymer nanofibers have attracted much attention because of remarkable characteristics such as a large surface area to volume ratio and high porosity. Nanofibers have been extensively used for different biomedical applications including wound dressing, tissue engineering and drug delivery. Among their fabrication methods, the introduction of electrospinning technique was an important step towards achieving the goal of large scale industrial production of nanofiber-based drug delivery systems used in mucosal applications. This chapter provides an overview on all aspects of mucosal drug and vaccine delivery using nanofibers.

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

  • OECD FORD branch

    20101 - Civil engineering

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Nanomaterials: Toxicity, Human Health and Environment

  • ISBN

    978-1-78984-616-4

  • Number of pages of the result

    28

  • Pages from-to

    171-198

  • Number of pages of the book

    231

  • Publisher name

    IntechOpen

  • Place of publication

    London, UK

  • UT code for WoS chapter