Could 5′-N and S ProTide analogues work as prodrugs of antiviral agents?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F20%3AN0000015" target="_blank" >RIV/00027162:_____/20:N0000015 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/20:00519335 RIV/61388963:_____/20:00519335
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0960894X19308753?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0960894X19308753?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bmcl.2019.126897" target="_blank" >10.1016/j.bmcl.2019.126897</a>
Alternative languages
Result language
angličtina
Original language name
Could 5′-N and S ProTide analogues work as prodrugs of antiviral agents?
Original language description
The nucleoside/nucleotide derived antiviral agents have been the most important components of antiviral therapy used in clinics. Recently, the focus of the medicinal chemists within this exciting research field has been affected mainly by the lack of effective therapies for the Hepatitis C virus (HCV) infection and several other “neglected” diseases caused by viruses such as Zika or Dengue. 2′-Methyl modified nucleosides and their monophosphate prodrugs (ProTides) have revolutionized the therapies for HCV in the last few years and, according to the latest research efforts, have also brought a promise for treatment of diseases caused by other members of Flaviviridae family. Here, we report on the design and synthesis of 5’-N and S modified ProTides derived from 2′-methyladenosine. We studied potential applicability of these derivatives as prodrugs of this archetypal antiviral compound.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10613 - Zoology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN
0960-894X
e-ISSN
1464-3405
Volume of the periodical
30
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
126897
UT code for WoS article
000507987200013
EID of the result in the Scopus database
2-s2.0-85077142100