All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Different chromosome damage in lymphocytes of newly diagnosed gastrointestinal and breast cancer patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F20%3AN0000209" target="_blank" >RIV/00027162:_____/20:N0000209 - isvavai.cz</a>

  • Alternative codes found

    RIV/00209805:_____/20:00078373

  • Result on the web

    <a href="http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=6571&category_id=160&option=com_virtuemart&vmcchk=1&Itemid=1" target="_blank" >http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=6571&category_id=160&option=com_virtuemart&vmcchk=1&Itemid=1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4149/neo_2020_190604N485" target="_blank" >10.4149/neo_2020_190604N485</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Different chromosome damage in lymphocytes of newly diagnosed gastrointestinal and breast cancer patients

  • Original language description

    Structural chromosome aberrations are predictive biomarker of cancer risk. Conventional chromosome analysis widely used for these purposes detects unstable chromosome aberrations that are eliminated during cell division. Stable aberrations that may persist in the body and tend to accumulate during a lifetime can be detected by fluorescence in situ hybridization (FISH). The aim of the study was to investigate the level of chromosome damage in newly diagnosed cancer patients and control subjects by FISH. Both groups of untreated cancer patients had increased frequency of aberrant cells. However, chromosome damage affected different cytogenetic endpoints. Stable translocations and cells with complex rearrangements were elevated in breast cancer patients whereas unstable chromosome aberrations (dicentric chromosomes and acentric fragments) were elevated in gastrointestinal cancer patients. These associations observed in nonsmokers were mostly not pronounced in smokers (with the exception of dicentric chromosomes in gastrointestinal patients). Exposure to tobacco smoke increased aberrations in healthy controls but not in the cancer patients. Our study suggests association between cancer and stable chromosomal rearrangements in breast cancer patients. Unstable aberrations elevated in gastrointestinal cancer patients may be at least partly ascribed to exposure to diagnostic X-rays.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30101 - Human genetics

Result continuities

  • Project

    <a href="/en/project/NV15-33968A" target="_blank" >NV15-33968A: The application of modern molecular genetic methods for the determination of genotoxic changes in at-risk populations</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Neoplasma

  • ISSN

    0028-2685

  • e-ISSN

    1338-4317

  • Volume of the periodical

    67

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    9

  • Pages from-to

    668–676

  • UT code for WoS article

    000542668500024

  • EID of the result in the Scopus database

    2-s2.0-85084924865