Structural chromosomal aberrations as potential risk markers in incident cancer patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295986" target="_blank" >RIV/00216208:11110/15:10295986 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/15:00451439 RIV/00216208:11130/15:10295986 RIV/00216208:11140/15:10295986 RIV/00216208:11120/15:43909567

Result on the web

<a href="http://dx.doi.org/10.1093/mutage/gev018" target="_blank" >http://dx.doi.org/10.1093/mutage/gev018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/mutage/gev018" target="_blank" >10.1093/mutage/gev018</a>

Result language

angličtina

Original language name

Structural chromosomal aberrations as potential risk markers in incident cancer patients

Original language description

Epidemiological prospective studies have shown that increased chromosomal aberrations (CAs) in peripheral blood lymphocytes may predict cancer risk. Here, we report CAs in newly diagnosed 101 colorectal, 87 lung and 158 breast cancer patients and corresponding healthy controls. Strong differences in distributions of aberrant cells (ACs), CAs, chromatid-type aberrations (CTAs) and chromosome-type aberrations (CSAs) were observed in lung and breast cancer patients as compared to healthy controls. In colorectal cancer (CRC) patients, only CTAs were significantly elevated. Binary logistic regression, adjusted for main confounders, indicates that all the analysed cytogenetic parameters along with smoking were significantly associated with breast and lung cancer risks. Significant differences in terminal deletions between breast cancer patients and corresponding female controls were recorded (0.39 vs. 0.18; P {= 0.05). We did not find any association of CAs with TNM (tumor nodus metastasis)

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mutagenesis

ISSN

0267-8357

e-ISSN

—

Volume of the periodical

30

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

557-563

UT code for WoS article

000357885900011

EID of the result in the Scopus database

2-s2.0-84936748157