Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539306" target="_blank" >RIV/68378041:_____/20:00539306 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/20:10415704 RIV/00216208:11110/20:10415704 RIV/00216208:11120/20:43920608 RIV/00064173:_____/20:N0000196
Result on the web
<a href="https://www.spandidos-publications.com/10.3892/or.2020.7774" target="_blank" >https://www.spandidos-publications.com/10.3892/or.2020.7774</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/or.2020.7774" target="_blank" >10.3892/or.2020.7774</a>
Alternative languages
Result language
angličtina
Original language name
Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients
Original language description
Accumulation of non-specific structural chromosomal aberrations (CAs) and telomere shortening contribute to genome instability, which constitutes as one of the hallmarks of cancer. CAs arise due to direct DNA damage or telomere shortening. CAs in peripheral blood lymphocytes (PBL), which are considered to be markers of exposure, have been previously reported to serve a role in the pathophysiology and progression of cancer through mechanisms that are poorly understood. In addition, the prognostic relevance of telomere length (TL) in patients with cancer remains to be elucidated. In the present study, CAs and TL in PBL isolated from patients with newly diagnosed cancer (151 breast, 96 colorectal, 90 lung) and 335 cancer-free control individuals were investigated. These results were then correlated with clinicopathological factors and follow-up data. The accumulation of CAs in PBL was observed with increased susceptibility to breast and lung cancer (P<0.0001), while individuals with longer TL were found to be at a higher risk of breast cancer (P<0.0001). Increased chromatid-type aberrations were also revealed to be associated with lower overall survival of patients with breast and colorectal cancers using a multivariate model. Compared with control individuals, no association was observed between TL and CAs or age in patients with cancer. In conclusion, the present study demonstrates the association between CAs/TL in PBL and the susceptibility, prognosis and survival of patients with breast, colorectal and lung cancer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oncology Reports
ISSN
1021-335X
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
5
Country of publishing house
GR - GREECE
Number of pages
12
Pages from-to
2219-2230
UT code for WoS article
000582501500039
EID of the result in the Scopus database
2-s2.0-85092093899