Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F20%3AN0000196" target="_blank" >RIV/00064173:_____/20:N0000196 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/20:00539306 RIV/00216208:11140/20:10415704 RIV/00216208:11110/20:10415704 RIV/00216208:11120/20:43920608

Result on the web

<a href="https://doi.org/10.3892/or.2020.7774" target="_blank" >https://doi.org/10.3892/or.2020.7774</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/or.2020.7774" target="_blank" >10.3892/or.2020.7774</a>

Result language

angličtina

Original language name

Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients

Original language description

Accumulation of non-specific structural chromosomal aberrations (CAs) and telomere shortening contribute to genome instability, which constitutes as one of the hallmarks of cancer. CAs arise due to direct DNA damage or telomere shortening. CAs in peripheral blood lymphocytes (PBL), which are considered to be markers of exposure, have been previously reported to serve a role in the pathophysiology and progression of cancer through mechanisms that are poorly understood. In addition, the prognostic relevance of telomere length (TL) in patients with cancer remains to be elucidated. In the present study, CAs and TL in PBL isolated from patients with newly diagnosed cancer (151 breast, 96 colorectal, 90 lung) and 335 cancer-free control individuals were investigated. These results were then correlated with clinicopathological factors and follow-up data. The accumulation of CAs in PBL was observed with increased susceptibility to breast and lung cancer (P<0.0001), while individuals with longer TL were found to be at a higher risk of breast cancer (P<0.0001). Increased chromatid-type aberrations were also revealed to be associated with lower overall survival of patients with breast and colorectal cancers using a multivariate model. Compared with control individuals, no association was observed between TL and CAs or age in patients with cancer. In conclusion, the present study demonstrates the association between CAs/TL in PBL and the susceptibility, prognosis and survival of patients with breast, colorectal and lung cancer.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology Reports

ISSN

1021-335X

e-ISSN

1791-2431

Volume of the periodical

44

Issue of the periodical within the volume

5

Country of publishing house

GR - GREECE

Number of pages

12

Pages from-to

2219-2230

UT code for WoS article

000582501500039

EID of the result in the Scopus database

2-s2.0-85092093899