GRANULATION TISSUE ENRICHED BY ASPIRIN AND OMEGA-3 FATTY ACIDS IN HEALING EXPERIMENTAL PERIODONTAL LESION
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F21%3AN0000083" target="_blank" >RIV/00027162:_____/21:N0000083 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/21:00074458 RIV/65269705:_____/21:00074458 RIV/00216224:14110/21:00120585
Result on the web
<a href="https://biomed.papers.upol.cz/artkey/bio-202102-0018_granulation-tissue-enriched-by-aspirin-and-omega-3-fatty-acids-in-healing-experimental-periodontal-lesion.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202102-0018_granulation-tissue-enriched-by-aspirin-and-omega-3-fatty-acids-in-healing-experimental-periodontal-lesion.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2020.003" target="_blank" >10.5507/bp.2020.003</a>
Alternative languages
Result language
angličtina
Original language name
GRANULATION TISSUE ENRICHED BY ASPIRIN AND OMEGA-3 FATTY ACIDS IN HEALING EXPERIMENTAL PERIODONTAL LESION
Original language description
Granulation tissue (GT) and specialized pro‑resolving mediators such as lipoxins and resolvins are key elements in the successful resolution of periodontitis. Aspirin‑triggered lipoxins and resolvins are even more powerful than their natural analogues. Their biosynthesis can be accelerated by omega-3 fatty acids. The aim of this study was to evaluate the use of GT enriched by aspirin and omega-3 fatty acids during the surgical treatment of periodontitis in an experimental animal model (rabbit). In each of 24 rabbits, two experimental periodontal defects were created. In total, 47 defects were treated with open-flap debridement and one of three procedures: (1) GT extracted and soaked with aspirin and omega-3 fatty acids (ASA+OMEGA3 group); (2) GT soaked with saline (PLACEBO group); or (3) GT left untreated (CONTROL group). Then, the GT was replaced in situ. Primary evaluated criteria were the probing pocket depth (PPD) and the clinical attachment level (CAL). Necropsies were harvested 2, 6, and 12 weeks after surgery. The samples were used for histological and molecular biological assessment. A trend of greater PPD and CAL in the ASA+OMEGA3 group was observed at 6 weeks. However, there was no significant difference between them. During the observation period, tissue levels of FGF-7, IL-1β and TIMP-1 showed a statistically significant decrease (P<0.05). For the other variables, the ASA+OMEGA3 group was comparable with the PLACEBO and CONTROL groups. This experiment did not demonstrate the superiority of the proposed approach. However, the enriched granulation tissue did not impair healing outcomes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30208 - Dentistry, oral surgery and medicine
Result continuities
Project
<a href="/en/project/NV16-28462A" target="_blank" >NV16-28462A: Chronic periodontitis therapy using resolvins and lipoxins</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers
ISSN
1213-8118
e-ISSN
1804-7521
Volume of the periodical
165
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
216-223
UT code for WoS article
000660244900018
EID of the result in the Scopus database
2-s2.0-85107146038