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GRANULATION TISSUE ENRICHED BY ASPIRIN AND OMEGA-3 FATTY ACIDS IN HEALING EXPERIMENTAL PERIODONTAL LESION

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F21%3AN0000083" target="_blank" >RIV/00027162:_____/21:N0000083 - isvavai.cz</a>

  • Alternative codes found

    RIV/00159816:_____/21:00074458 RIV/65269705:_____/21:00074458 RIV/00216224:14110/21:00120585

  • Result on the web

    <a href="https://biomed.papers.upol.cz/artkey/bio-202102-0018_granulation-tissue-enriched-by-aspirin-and-omega-3-fatty-acids-in-healing-experimental-periodontal-lesion.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202102-0018_granulation-tissue-enriched-by-aspirin-and-omega-3-fatty-acids-in-healing-experimental-periodontal-lesion.php</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5507/bp.2020.003" target="_blank" >10.5507/bp.2020.003</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    GRANULATION TISSUE ENRICHED BY ASPIRIN AND OMEGA-3 FATTY ACIDS IN HEALING EXPERIMENTAL PERIODONTAL LESION

  • Original language description

    Granulation tissue (GT) and specialized pro‑resolving mediators such as lipoxins and resolvins are key elements in the successful resolution of periodontitis. Aspirin‑triggered lipoxins and resolvins are even more powerful than their natural analogues. Their biosynthesis can be accelerated by omega-3 fatty acids. The aim of this study was to evaluate the use of GT enriched by aspirin and omega-3 fatty acids during the surgical treatment of periodontitis in an experimental animal model (rabbit). In each of 24 rabbits, two experimental periodontal defects were created. In total, 47 defects were treated with open-flap debridement and one of three procedures: (1) GT extracted and soaked with aspirin and omega-3 fatty acids (ASA+OMEGA3 group); (2) GT soaked with saline (PLACEBO group); or (3) GT left untreated (CONTROL group). Then, the GT was replaced in situ. Primary evaluated criteria were the probing pocket depth (PPD) and the clinical attachment level (CAL). Necropsies were harvested 2, 6, and 12 weeks after surgery. The samples were used for histological and molecular biological assessment. A trend of greater PPD and CAL in the ASA+OMEGA3 group was observed at 6 weeks. However, there was no significant difference between them. During the observation period, tissue levels of FGF-7, IL-1β and TIMP-1 showed a statistically significant decrease (P<0.05). For the other variables, the ASA+OMEGA3 group was comparable with the PLACEBO and CONTROL groups. This experiment did not demonstrate the superiority of the proposed approach. However, the enriched granulation tissue did not impair healing outcomes.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30208 - Dentistry, oral surgery and medicine

Result continuities

  • Project

    <a href="/en/project/NV16-28462A" target="_blank" >NV16-28462A: Chronic periodontitis therapy using resolvins and lipoxins</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biomedical Papers

  • ISSN

    1213-8118

  • e-ISSN

    1804-7521

  • Volume of the periodical

    165

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    8

  • Pages from-to

    216-223

  • UT code for WoS article

    000660244900018

  • EID of the result in the Scopus database

    2-s2.0-85107146038