Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074458" target="_blank" >RIV/00159816:_____/21:00074458 - isvavai.cz</a>

Alternative codes found

RIV/00027162:_____/21:N0000083 RIV/00216224:14110/21:00120585 RIV/65269705:_____/21:00074458

Result on the web

<a href="https://biomed.papers.upol.cz/artkey/bio-202102-0018_granulation-tissue-enriched-by-aspirin-and-omega-3-fatty-acids-in-healing-experimental-periodontal-lesion.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202102-0018_granulation-tissue-enriched-by-aspirin-and-omega-3-fatty-acids-in-healing-experimental-periodontal-lesion.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2020.003" target="_blank" >10.5507/bp.2020.003</a>

Result language

angličtina

Original language name

Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion

Original language description

Aims. Granulation tissue (GT) and specialized pro-resolving mediators such as lipoxins and resolvins are key elements in the successful resolution of periodontitis. Aspirin-triggered lipoxins and resolvins are even more powerful than their natural analogues. Their biosynthesis can be accelerated by omega-3 fatty acids. The aim of this study was to evaluate the use of GT enriched by aspirin and omega-3 fatty acids during the surgical treatment of periodontitis in an experimental animal model (rabbit). Methods. In each of 24 rabbits, two experimental periodontal defects were created. In total, 47 defects were treated with open-flap debridement and one of three procedures: (1) GT extracted and soaked with aspirin and omega-3 fatty acids (ASA+OMEGA3 group); (2) GT soaked with saline (PLACEBO group); or (3) GT left untreated (CONTROL group). Then, the GT was replaced in situ. Primary evaluated criteria were the probing pocket depth (PPD) and the clinical attachment level (CAL). Necropsies were harvested 2, 6, and 12 weeks after surgery. The samples were used for histological and molecular biological assessment. Results. A trend of greater PPD and CAL in the ASA+OMEGA3 group was observed at 6 weeks. However, there was no significant difference between them. During the observation period, tissue levels of FGF-7, IL-1 beta and TIMP-1 showed a statistically significant decrease (P&lt;0.05). For the other variables, the ASA+OMEGA3 group was comparable with the PLACEBO and CONTROL groups. Conclusion. This experiment did not demonstrate the superiority of the proposed approach. However, the enriched granulation tissue did not impair healing outcomes.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30100 - Basic medicine

Project

<a href="/en/project/NV16-28462A" target="_blank" >NV16-28462A: Chronic periodontitis therapy using resolvins and lipoxins</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical papers

ISSN

1213-8118

e-ISSN

—

Volume of the periodical

165

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

216-223

UT code for WoS article

000660244900018

EID of the result in the Scopus database

2-s2.0-85107146038