Escherichia coli Strains Producing Selected Bacteriocins Inhibit Porcine Enterotoxigenic Escherichia coli (ETEC) under both In Vitro and In Vivo Conditions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F21%3AN0000259" target="_blank" >RIV/00027162:_____/21:N0000259 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/21:00123081
Result on the web
<a href="https://journals.asm.org/doi/10.1128/AEM.03121-20" target="_blank" >https://journals.asm.org/doi/10.1128/AEM.03121-20</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/AEM.03121-20" target="_blank" >10.1128/AEM.03121-20</a>
Alternative languages
Result language
angličtina
Original language name
Escherichia coli Strains Producing Selected Bacteriocins Inhibit Porcine Enterotoxigenic Escherichia coli (ETEC) under both In Vitro and In Vivo Conditions
Original language description
Enterotoxigenic Escherichia coli (ETEC) and Shiga toxin-producing E. coli (STEC) strains are the causative agents of severe foodborne diseases in both humans and animals. In this study, porcine pathogenic E. coli strains (n = 277) as well as porcine commensal strains (n = 195) were tested for their susceptibility to 34 bacteriocin monoproducers to identify the most suitable bacteriocin types inhibiting porcine pathogens. Under in vitro condition, the set of pathogenic E. coli was found to be significantly more susceptible to a majority of tested bacteriocins when compared to commensal E. coli. Based on production of bacteriocins with specific activity against pathogen, three potentially probiotic commensal E. coli strains of human origin were selected. These strains were found to be able to outcompete ETEC strains expressing F4 or F18 fimbriae in liquid culture and also decrease severity and duration of diarrhea in piglets during experimental ETEC infection as well as pathogen numbers in the last day of in vivo experimentation. While the extent of the probiotic effect was different for each strain, the cocktail of all three strains showed the most pronounced beneficial effects suggesting synergy between tested E. coli strains.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
ISSN
0099-2240
e-ISSN
1098-5336
Volume of the periodical
87
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
"e03121-20"
UT code for WoS article
000693249500022
EID of the result in the Scopus database
2-s2.0-85111784496