Effects of IFNγ and IL4 rich microenvironment on porcine monocyte-derived dendritic cell activation in vitro
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000015" target="_blank" >RIV/00027162:_____/22:N0000015 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0034528822000479?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0034528822000479?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.rvsc.2022.02.010" target="_blank" >10.1016/j.rvsc.2022.02.010</a>
Alternative languages
Result language
angličtina
Original language name
Effects of IFNγ and IL4 rich microenvironment on porcine monocyte-derived dendritic cell activation in vitro
Original language description
Dendritic cells (DCs) represent a heterogeneous group of major antigen-presenting cells, responding to different stimuli in their microenvironment. They are able to activate naïve T-cells and drive their polarization towards effector types. However, the effect of different Th-polarizing cytokine microenvironment on porcine DCs remains poorly described. Therefore, the effect of IFNγ or IL4 rich microenvironment on porcine monocyte-derived dendritic cells and their activation, antigen recognition and cytokine secretion towards T-cell polarization were studied in vitro. IFNγ-rich microenvironment induced a higher proinflammatory response and release of Th1/Th17-polarizing cytokines (IL1β, IL12p35, IL23p19), while anti-inflammatory properties (IL10, TGFβ) was not affected by a cytokine microenvironment. From the achieved results, we propose that different cytokine microenvironment has the potential to modulate dendritic cells and their ability to activate T-cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Research in Veterinary Science
ISSN
0034-5288
e-ISSN
1532-2661
Volume of the periodical
145
Issue of the periodical within the volume
July 2022
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
54-62
UT code for WoS article
000798224400008
EID of the result in the Scopus database
2-s2.0-85124491728