Association between sperm mitochondrial DNA copy number and deletion rate and industrial air pollution dynamics

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000040" target="_blank" >RIV/00027162:_____/22:N0000040 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41598-022-12328-9" target="_blank" >https://www.nature.com/articles/s41598-022-12328-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-022-12328-9" target="_blank" >10.1038/s41598-022-12328-9</a>

Result language
angličtina
Original language name
Association between sperm mitochondrial DNA copy number and deletion rate and industrial air pollution dynamics
Original language description
The efects of air pollution on men’s reproductive health can be monitored by evaluating semen quality and sperm DNA damage. We used real-time PCR to analyse the efects of air pollution on sperm mitochondrial DNA copy number (mtDNAcn) and deletion (mtDNAdel) rates in semen samples collected from 54 men in two seasons with diferent levels of industrial and trafc air pollution. MtDNAdel rates were signifcantly higher following the high exposure period and were positively correlated with mtDNAcn. However, we did not fnd any diference in mtDNAcn between the two seasons. MtDNAcn was positively correlated with the DNA fragmentation index and the rates of sperm with chromatin condensation defects, previously assessed by sperm chromatin structure assay, and negatively correlated with sperm concentration, progressive motility, viability, and normal morphology. This indicates that mtDNAcn is more closely associated with male fertility than mtDNAdel rates. In contrast, mtDNAdel might be a more sensitive biomarker of air pollution exposure in urban industrial environments.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30304 - Public and environmental health

Project
<a href="/en/project/EF16_019%2F0000798" target="_blank" >EF16_019/0000798: Healthy Aging in Industrial Environment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)