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Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F05%3A06000011" target="_blank" >RIV/00027162:_____/05:06000011 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality

  • Original language description

    This study examined potential associations between exposure to episodes of air pollution and alterations in semen quality. The air pollution, resulting from combustion of coal for industry and home heating in the Teplice, was much higher during thewinterthan at other times of year. Young men from Teplice were sampled up to seven times over two years allowing evaluation of semen quality after periods of exposure to both low and high air pollution. Routine semen analysis and tests for spermaneuploidy andchromatin integrity were performed, comparing measurements within each man. Using repeated measures analysis, a significant association was found between exposure to periods of high air pollution and the percentage of sperm with DNAfragmentation according to Sperm Chromatin Structure Assay. Exposure to intermittent air pollution may result in sperm DNA damage and thereby increase the rates of male-mediated infertility, miscarriage, and other adverse reproductive outcomes.

  • Czech name

    Asociace episodického znečištění ovzduší se vzrůstem DNA fragmentace v lidských spermiích bez dalších změn v kvalitě semene

  • Czech description

    Byla studována asociace mezi sezoním zvýšením znečištění ovzduší a změnami v kvalitě spermií u mladých mužů v okrese Teplice. Sledovaní muži byli vyšetření 7 krát v průběhu dvou let. Ze všech sledovaných parametrů kvality spermií byla zjištěnasignifikantní asociace mezi znečištění ovzduší a fragmentací chromatinu ve spermiích. Poruchy integrity chromatinu ve spermiích byly identifikovány jako biomárker expozice genotoxickými látkami, které mohou snižovat plodnost v oblastech s vysokýmznečištěním životního prostředí.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    DN - Environmental impact on health

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Human Reproduction

  • ISSN

    0268-1161

  • e-ISSN

  • Volume of the periodical

    20

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    2776-2783

  • UT code for WoS article

  • EID of the result in the Scopus database