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Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F10%3A00340197" target="_blank" >RIV/68378041:_____/10:00340197 - isvavai.cz</a>

  • Alternative codes found

    RIV/00027162:_____/10:#0000628

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution

  • Original language description

    The impact of PAHs and VOCs on sperm quality in a group of city policemen in Prague during winter season (high exposure) compared to spring season (low exposure) were studied. Polymorphisms in metabolic genes (CYP1A1, EPHX1, GSTM1, GSTP1, GSTT1), folic acid metabolism genes (MTR, MTHFR) and DNA repair genes (XRCC1, XPD6, XPD23, hOGG1) were evaluated as potential modifiers of associations between air pollution exposure and changes in sperm quality. No significant differences were found in any standard semen parameters between the sampling periods except for vitality of sperms.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    DN - Environmental impact on health

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/1QS500390506" target="_blank" >1QS500390506: Impact of environmental and genetic factors on men fertility</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Mutation Research

  • ISSN

    0027-5107

  • e-ISSN

  • Volume of the periodical

    683

  • Issue of the periodical within the volume

    1-2

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    7

  • Pages from-to

  • UT code for WoS article

    000273845500002

  • EID of the result in the Scopus database