Early immune response of two common carp breeds to koi herpesvirus infection
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000077" target="_blank" >RIV/00027162:_____/22:N0000077 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/22:00126434 RIV/62157124:16270/22:43880113
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1050464822004533?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1050464822004533?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fsi.2022.07.064" target="_blank" >10.1016/j.fsi.2022.07.064</a>
Alternative languages
Result language
angličtina
Original language name
Early immune response of two common carp breeds to koi herpesvirus infection
Original language description
Economic importance of common carp (Cyprinus carpio L.) increases every year. Viral diseases are major threat for carp aquaculture and cause significant economic losses. Koi herpesvirus (KHV) is one of the most serious carp diseases. Current study is focused on confirmation of possible differences in early immune response to KHV depending on level of resistance. Class I interferon signalling, complement cascade and cell-mediated cytotoxicity are hypothesized as major mechanisms of early innate immune response against KHV. Different breeds of common carp show distinct level of resistance to KHV. Two breeds of common carp with completely different susceptibility to KHV were chosen for current research: amur wild carp (AS) as highly resistant and koi carp (KOI) as very susceptible breed. KHV infection caused no mortalities, but the viral load in selected tissues increased during infection. Levels of expressions of chosen genes was examined using qRT-PCR and overall change in protein expression profiles was analysed by mass spectrometry. Significant differences in immune response between AS and KOI were detected mostly at the level of protein expression. Although cell-mediated cytotoxicity showed minimal influence during KHV infection, many immune response parameters related to class I interferon signalling pathway and complement cascade were increased earlier during KHV infection in AS comparing to KOI.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
<a href="/en/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Sustainable production of healthy fish in various aquaculture systems - PROFISH</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Fish and Shellfish Immunology
ISSN
1050-4648
e-ISSN
1095-9947
Volume of the periodical
128
Issue of the periodical within the volume
September 2022
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
206-215
UT code for WoS article
000888570700005
EID of the result in the Scopus database
2-s2.0-85135720594