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Early immune response of two common carp breeds to koi herpesvirus infection

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F23%3AN0000079" target="_blank" >RIV/00027162:_____/23:N0000079 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.eurl-fish-crustacean.eu/fish/annual-workshop" target="_blank" >https://www.eurl-fish-crustacean.eu/fish/annual-workshop</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Early immune response of two common carp breeds to koi herpesvirus infection

  • Original language description

    Common carp is the most economically important fish farmed in the Czech Republic. The presence of koi herpesvirus in the country was confirmed in the early 2000s and 0 to 16 outbreak sites are detected and eradicated every year since. Although the factors of resistance of various carp breeds against the virus were studied extensively, including infection trials and mapping of quantitative trait loci, evolving analytic methods present an opportunity to further characterize the reaction of the immune system of carp to the infection. Koi carp, previously confirmed as highly susceptible to KHV, and amur wild carp (confirmed resistant) were selected for this study and intraperitoneally infected with low virulence KHV strain. Viral load, expression of selected immune genes (qPCR) and changes in expression profile of proteins (mass spectrometry) were monitored in head kidney, spleen and gills of the fish 3 and 7 days post infection. Although the viral loads increased during infection, no mortalities were observed. Few significant difference were detected at the gene expression levels, but protein expression revealed earlier onset of parameters related to class I interferon signalling pathway and complement cascade in amur carp compared to common carp. This might suggest the immunological foundation of increased amur carp resistance to KHV.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    40103 - Fishery

Result continuities

  • Project

    <a href="/en/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Sustainable production of healthy fish in various aquaculture systems - PROFISH</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů