Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F23%3AN0000163" target="_blank" >RIV/00027162:_____/23:N0000163 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/23:00579681 RIV/00216224:14310/23:00132670 RIV/62157124:16170/23:43881032
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0264410X23010897?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0264410X23010897?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.vaccine.2023.09.019" target="_blank" >10.1016/j.vaccine.2023.09.019</a>

Result language
angličtina
Original language name
Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs
Original language description
Tick-borne encephalitis (TBE) is a severe neuroinfection of humans that occurs in Europe and Asia. Dogs are also commonly infected with tick-borne encephalitis virus (TBEV) in TBE-endemic areas. These infections are usually asymptomatic, but sometimes show clinical signs similar to those seen in humans and can be fatal. To date, there is no TBEV vaccine available for use in dogs. To address this unmet need, we have developed a TBEV vaccine candidate for dogs based on inactivated whole virus antigen. The safety, immunogenicity, and efficacy of the vaccine candidate were tested in mice as the preclinical model and in dogs as the target organism. The vaccine was well tolerated in both animal species and elicited the production of specific anti-TBEV antibodies with virus neutralising activity. Vaccination of mice provided complete protection against the development of fatal TBE. Immunisation of dogs prevented the development of viremia after challenge infection. Therefore, the developed vaccine candidate is promising to protect dogs from severe TBEV infections.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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