Interleukin-17 producing cells in swine induced by microbiota during the early postnatal period - a brief research report
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F23%3AN0000205" target="_blank" >RIV/00027162:_____/23:N0000205 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/23:00576421
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2023.1214444/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fimmu.2023.1214444/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2023.1214444" target="_blank" >10.3389/fimmu.2023.1214444</a>
Alternative languages
Result language
angličtina
Original language name
Interleukin-17 producing cells in swine induced by microbiota during the early postnatal period - a brief research report
Original language description
Interleukin-17A (IL-17) is a pro-inflammatory cytokine involved in the immune response to many pathogens playing also a role in certain chronic and autoimmune diseases. The presented study focused on the early postnatal development of IL-17 producing cells in swine. In agreement with previous studies, αβ T-helper (CD3+CD4+) and γδ T (CD3+TCRγδ+) cells were found to be the major producers of IL-17. In newborn conventional piglets, αβ T-helper cells positive for IL-17 were almost undetectable, but their frequency increased markedly with age in all issues examined, i.e., blood, spleen, and mesenteric lymph nodes (MLN). Additional analyses of CD8 and CD27 expression showed that the main αβ T-helper producers of IL-17 has CD8+CD27- phenotype in all tissues. IL-17 positive CD8+CD27+ αβ T-helper subpopulation was found only in blood and spleen. The production of IL17 in CD8-CD27+ αβ T-helper cells was always minor. In contrast, γδ T cells positive for IL-17 did not show a similar age-dependent increase in blood and spleen, whereas they increased in MLN. Because of the age-dependent increase in conventional animals, we included a comparison with germ-free piglets to show that the increase in IL-17 positive cells was clearly depended on the presence of the microbiota as the production in germ-free animals was negligible without any age-dependent increase.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
<a href="/en/project/GA20-03282S" target="_blank" >GA20-03282S: Porcine reproductive and respiratory syndrome virus (PRRSV) alters thymocyte development and repertoire of T lymphocytes</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Immunology
ISSN
1664-3224
e-ISSN
1664-3224
Volume of the periodical
14
Issue of the periodical within the volume
20 September 2023
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
"1214444"
UT code for WoS article
001074599300001
EID of the result in the Scopus database
2-s2.0-85173976231