Spontaneous Regression of Swine Melanoma: The Role of Tumour-infiltrating T and NK Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00573867" target="_blank" >RIV/67985904:_____/23:00573867 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10465446
Result on the web
<a href="https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=54086803247" target="_blank" >https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=54086803247</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/anticanres.16199" target="_blank" >10.21873/anticanres.16199</a>
Alternative languages
Result language
angličtina
Original language name
Spontaneous Regression of Swine Melanoma: The Role of Tumour-infiltrating T and NK Cells
Original language description
Background/Aim: Melanoma is a skin cancer without effective therapy, showing high immunogenicity and mostly partial spontaneous regression (SR). The exact mechanisms of SR are still not well understood, therefore, the use of animal melanoma models is necessary to unravel the immunological processes during SR. Materials and Methods: Skin melanoma samples (n=57) and peripheral blood samples (n=57) from the same animals were collected. Melanoma -bearing Libechov Minipigs (MeLiM) aged 3, 4, 6, 8, 10, 12, 20, and 32 weeks were used, and samples were analysed by flow cytometry for detection of immune cell subpopulations. Results: The proportion of CD3-CD8+ (NK) cells in melanoma samples was found to be higher compared to blood samples at 6-8 weeks of age and then at 12 weeks of age. The population of CD4+CD8+ (effector/memory T helper) cells and CD4-CD8+ (cytotoxic T and NK) cells was also increased in melanoma compared to blood samples in 10-32 -week-old pigs. The proportion of CD4-CD8+ cells in melanoma samples, then augmented until the 32nd week. On the contrary, the proportion of CD4+CD8- (naive T helper) cells was lower in melanoma samples versus blood samples in 6-32-week-old animals. Conclusion: Cytotoxic T cells were the most abundant population of tumour infiltrating immune cells found in MeLiM melanomas of animals aged 10-32 weeks, probably causing the destruction of melanoma cells. Furthermore, the development of specific (adaptive) immune response represented mainly by cytotoxic T cells seems to be crucial for the successful SR of porcine melanoma.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/EF16_019%2F0000785" target="_blank" >EF16_019/0000785: Center for Tumor Ecology - Research of the cancer microenvironment supporting cancer growth and spread</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anticancer Research
ISSN
0250-7005
e-ISSN
1791-7530
Volume of the periodical
43
Issue of the periodical within the volume
2
Country of publishing house
GR - GREECE
Number of pages
8
Pages from-to
631-638
UT code for WoS article
001013271000007
EID of the result in the Scopus database
2-s2.0-85146879104