Intelligent Magnetic Microrobots with Fluorescent Internal Memory for Monitoring Intragastric Acidity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000068" target="_blank" >RIV/00027162:_____/24:N0000068 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/24:PU151485 RIV/00216224:90127/24:00139075 RIV/61989100:27240/24:10255082
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/adfm.202401463" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adfm.202401463</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adfm.202401463" target="_blank" >10.1002/adfm.202401463</a>
Alternative languages
Result language
angličtina
Original language name
Intelligent Magnetic Microrobots with Fluorescent Internal Memory for Monitoring Intragastric Acidity
Original language description
This study investigates the dynamic fluctuations of pH caused by gastric acid secretion, a process of both biological and clinical significance, with microrobots. Abnormal patterns of acidity often indicate gastrointestinal diseases, underlying the importance of precise intragastric pH monitoring. Traditional methods using fluorescent probes face challenges due to their faint solid-state fluorescence, limited target specificity, and accuracy. To overcome these obstacles, pH-responsive fluorescent organic microparticles decorated with magnetite (Fe3O4) nanoparticles are engineered. These microrobots exhibit a unique fluorescence switching capability at a critical pH, enabling the monitoring of gastric acidity. The magnetic part of these microrobots ensures magnetic maneuverability to enable targeted navigation. The microrobots’ fluorescence switching mechanism is elucidated through comprehensive spectroscopy, microscopy, and X-ray diffraction analyses, revealing molecular-level structural transformations upon interaction with gastric acid and antacids. These transformations, specifically protonation and deprotonation of the microrobots’ fluorescent components, prompt a distinct fluorescence response correlating with pH shifts. In vitro and ex vivo experiments, simulating stomach conditions, confirm the microrobots’ efficacy in pH-responsive imaging. The results showcase the promising diagnostic potential of microrobots for gastrointestinal tract diseases, marking a significant advancement in imaging-based medical diagnostics at targeted locations.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
<a href="/en/project/EF15_003%2F0000495" target="_blank" >EF15_003/0000495: FIT (Pharmacology, Immunotherapy, nanoToxicology)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Functional Materials
ISSN
1616-301X
e-ISSN
1616-3028
Volume of the periodical
34
Issue of the periodical within the volume
29
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
"2401463"
UT code for WoS article
001224731500001
EID of the result in the Scopus database
2-s2.0-85193268527