Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F23%3AN0000021" target="_blank" >RIV/00027162:_____/23:N0000021 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/23:PU147336 RIV/60077344:_____/22:00580525 RIV/00216224:14310/23:00130535 RIV/62156489:43210/23:43922564 RIV/61989100:27240/23:10252773
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/adhm.202202682" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adhm.202202682</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adhm.202202682" target="_blank" >10.1002/adhm.202202682</a>
Alternative languages
Result language
angličtina
Original language name
Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract
Original language description
Magnetic microrobots offer wireless navigation capability in hard-to-reach areas of the human body for targeted therapeutics and diagnostics. Though in vivo imaging is required for guidance of the magnetic microrobots toward the target areas, most of the imaging techniques are inadequate to reveal the potential locomotion routes. Here, we propose the utilization of radiopaque magnetic microrobots along with micro-computed tomography (microCT) for localized in vivo imaging applications. The microrobots consist of a contrast agent, barium sulfate (BaSO4) microparticles, magnetized by a decoration with magnetite (Fe3O4) nanoparticles. The magnetic features lead to actuation under rotating magnetic fields and enable precise navigation in a microfluidic channel used to simulate confined spaces of the human body. Furthermore, the intrinsic radiopacity of the microrobots provides the possibility to reveal internal structures in vitro by generating X-ray contrast. In vivo experiments demonstrate localization of the microrobots in a specific part of the gastrointestinal (GI) tract upon the influence of the magnetic field, indicating the efficient control even in the presence of natural peristaltic movements. The microrobots reported here highlight that smart microrobotic contrast agents can improve the current imaging-based diagnostic techniques by providing untethered controllability in vivo.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Healthcare Materials
ISSN
2192-2640
e-ISSN
2192-2659
Volume of the periodical
12
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
"2202682"
UT code for WoS article
000903078100001
EID of the result in the Scopus database
2-s2.0-85145028340