Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00580525" target="_blank" >RIV/60077344:_____/22:00580525 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/23:PU147336 RIV/00027162:_____/23:N0000021 RIV/00216224:14310/23:00130535 RIV/62156489:43210/23:43922564 RIV/61989100:27240/23:10252773

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1002/adhm.202202682" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adhm.202202682</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adhm.202202682" target="_blank" >10.1002/adhm.202202682</a>

Result language

angličtina

Original language name

Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract

Original language description

Magnetic nanorobots offer wireless navigation capability in hard-to-reach areas of the human body for targeted therapy and diagnosis. Though in vivo imaging is required for guidance of the magnetic nanorobots toward the target areas, most of the imaging techniques are inadequate to reveal the potential locomotion routes. This work proposes the use of radiopaque magnetic nanorobots along with microcomputed tomography (microCT) for localized in vivo imaging applications. The nanorobots consist of a contrast agent, barium sulfate (BaSO4), magnetized by the decoration of magnetite (Fe3O4) particles. The magnetic features lead to actuation under rotating magnetic fields and enable precise navigation in a microfluidic channel used to simulate confined spaces of the body. In this channel, the intrinsic radiopacity of the nanorobots also provides the possibility to reveal the internal structures by X-ray contrast. Furthermore, in vitro analysis indicates nontoxicity of the nanorobots. In vivo experiments demonstrate localization of the nanorobots in a specific part of the gastrointestinal (GI) tract upon the influence of the magnetic field, indicating the efficient control even in the presence of natural peristaltic movements. The nanorobots reported here highlight that smart nanorobotic contrast agents can improve the current imaging-based diagnosis techniques by providing untethered controllability in vivo.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Advanced Healthcare Materials

ISSN

2192-2640

e-ISSN

2192-2659

Volume of the periodical

12

Issue of the periodical within the volume

MAR

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

2202682

UT code for WoS article

000903078100001

EID of the result in the Scopus database

2-s2.0-85145028340