Gold nanoparticles functionalised with urea-based gemini surfactants

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F25%3AN0000084" target="_blank" >RIV/00027162:_____/25:N0000084 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0167732225017301?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0167732225017301?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molliq.2025.128553" target="_blank" >10.1016/j.molliq.2025.128553</a>

Result language

angličtina

Original language name

Gold nanoparticles functionalised with urea-based gemini surfactants

Original language description

The present study is focused on the synthesis gold nanoparticles (AuNPs) and investigation of their physical parameters and biological activity after functionalisation with cationic bisammonium gemini surfactants with urea groups in their alkyl chains and a variable length of polymethylene spacer in the range 2–10 methylene groups. UV-VIS spectroscopy confirmed the formation of stable gold nanodispersions with plasmon resonance peaks in the interval of wavelengths 540–560 nm at all investigated surfactant spacer length values. The region of stable gold nanodispersions covered the range of surfactant to gold molar ratio values up to 3.3. At higher molar ratio values, nanoparticle agglomeration was observed. Dynamic light scattering measurements and scanning electron microscopy confirmed the formation of AuNPs with the size between 45 and 117 nm which depended on the molar ratio and the spacer length of stabilising surfactant. Notable increase in AuNPs size was observed at the high surfactant to gold molar ratio because of nanoparticles agglomeration and instability of nanodispersions. A moderate size increase of AuNPs functionalised with urea gemini surfactant with a short spacer is observed. Positive zeta potential values between +30 and + 50 mV also indicated the formation of stable AuNPs. Cytotoxicity determination revealed the highest activity for AuNPs functionalised with urea gemini surfactant with the short spacer of 2 CH2 groups. As the surfactant spacer length increased, cytotoxicity differences between AuNPs functionalised with individual gemini surfactants became insignificant as a consequence of increasing hydrophobicity of the capping agent. However, anti-inflammatory potential of urea gemini capped AuNPs did not significantly exceed the level of standards. On the other hand, some of tested AuNPs showed chondroprotective potential. The presence of urea groups in the molecular structure of stabilising surfactants provides new opportunities of controlling the composition of AuNPs during their synthesis to receive nanoparticle systems with tailored physical parameters and interesting levels of biological activity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Molecular Liquids

ISSN

0167-7322

e-ISSN

1873-3166

Volume of the periodical

473

Issue of the periodical within the volume

Part C

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

12

Pages from-to

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UT code for WoS article

999

EID of the result in the Scopus database

2-s2.0-105016315422