Radiofrequency and targeted ultrasound enhance natural hyaluronic production: a pilot porcine study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F25%3AN0000145" target="_blank" >RIV/00027162:_____/25:N0000145 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/25:00143294
Result on the web
<a href="https://link.springer.com/article/10.1007/s40477-025-01083-y" target="_blank" >https://link.springer.com/article/10.1007/s40477-025-01083-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s40477-025-01083-y" target="_blank" >10.1007/s40477-025-01083-y</a>
Alternative languages
Result language
angličtina
Original language name
Radiofrequency and targeted ultrasound enhance natural hyaluronic production: a pilot porcine study
Original language description
Background: Loss of skin elasticity and youthful appearance is closely linked to reduced hyaluronic acid (HA) levels in the dermis. While topical HA products offer temporary effects, they do not address the root cause of HA depletion. Objective: The present study aims to describe how to induce HA synthesis through fibroblast stimulation. Materials and Methods: Twelve sows were divided into two groups. One group (n = 9) received four consecutive Radiofrequency (RF) and Targeted Ultrasound (TUS) treatments, the other group (n = 3) received four RF treatments only. Samples were collected via punch biopsy from the treated area of each animal at the baseline, 1-month, and 2-month follow-up. Samples were then processed and prepared for enzyme-linked immunosorbent assay as well as hyaluronic acid binding protein with diaminobenzidine (HABP-DAP) staining, which allows for visualization of HA within tissue. Findings: The group receiving RF + TUS treatment has demonstrated an increase from an average of 83.0 µg/g at the baseline to 163.0 µg/g at the 2-month follow-up of HA concentration in the skin. Histology samples clearly demonstrate higher tissue density with an increase of brown pigment due to the HABP-DAP stain, representing HA in the skin. In comparison, the RF standalone treatment group has shown no significant increase in HA concentrations. Conclusion: Study results show no significant increase in HA production following the RF stand alone treatment. Whereas the RF + TUS treatment group induced a significant HA production response as well as histophysiological changes in the dermis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Ultrasound
ISSN
1971-3495
e-ISSN
1876-7931
Volume of the periodical
28
Issue of the periodical within the volume
4
Country of publishing house
CH - SWITZERLAND
Number of pages
6
Pages from-to
1001-1006
UT code for WoS article
001575758400001
EID of the result in the Scopus database
2-s2.0-105016819600