Fibroblast Growth Factor 23 and Matrix-Metalloproteinases in Patients with Chronic Kidney Disease: Are They Associated with Cardiovascular Disease?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F09%3A4332" target="_blank" >RIV/00064165:_____/09:4332 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/09:00201589 RIV/00216208:11110/09:4332 RIV/00023001:_____/09:00002765

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Fibroblast Growth Factor 23 and Matrix-Metalloproteinases in Patients with Chronic Kidney Disease: Are They Associated with Cardiovascular Disease?

Original language description

Background: High cardiovascular risk in patients with chronic kidney disease (CKD) may be related to mineral disorder and microinflammation. Fibroblast growth factor 23 (FGF23) is a phosphatonin and inhibitor of calcitriol synthesis, which is associatedwith poor prognosis in CKD patients starting dialysis. Matrix-metalloproteinases (MMP-2, MMP-9) con tribute to myocardial remodeling and arterial calcification. FGF-23 and MMPs levels are altered in CKD, however, little is known about their association and relation to cardiovascular (CV) disease. Methods: Standard laboratory parameters, plasma levels of MMP-2, MMP-9, FGF-23, PAPP-A and CV disease history were assessed in 80 patients with CKD 1-5 and 44 healthy control subjects. Results: FGF-23 and MMP-2(assessed by ELISA) were higher in CKD patients compared to controls. FGF-23 increased from CKD 3, whereas MMP-2 increased only in CKD 5. FGF-23 was positively associated with MMP-2, adjusted to age, eGFR, phosphatemia, calcitriol and pa

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/NS10043" target="_blank" >NS10043: Genetic predisposition and new biochemical markers of cardiovascular risk in patients with chronic kidney diseases.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Kidney and Blood Pressure Research

ISSN

1420-4096

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

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UT code for WoS article

000270553600008

EID of the result in the Scopus database

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