Methotrexate bioavailability after oral and subcutaneous administration in children with juvenile idiopathic arthritis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F09%3A5396" target="_blank" >RIV/00064165:_____/09:5396 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/09:5396

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Methotrexate bioavailability after oral and subcutaneous administration in children with juvenile idiopathic arthritis

Original language description

The differences in the pharmacokinetic measures of early systemic exposure between oral and subcutaneous routes support the view that lower and saturable intestinal absorption of oral MTX limits its bioavailability and efficacy within the range of standard doses used to treat children with JIA. In light of this evidence it can be recommended to use parenteral route of administration when MTX dose around above 10-15mg/m2 is needed to achieve sufficient response.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FG - Paediatrics

OECD FORD branch

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Project

<a href="/en/project/NE6681" target="_blank" >NE6681: Relationship of intracellular methotrexate concentration to clinical and laboratory parameters of disease activity in children with idiopathic arthritis</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical and Experimental Rheumatology

ISSN

0392-856X

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

6

Country of publishing house

IT - ITALY

Number of pages

7

Pages from-to

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UT code for WoS article

000274264700028

EID of the result in the Scopus database

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