Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F10%3A7161" target="_blank" >RIV/00064165:_____/10:7161 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/10:00002325 RIV/00216208:11110/10:7161

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels.

Original language description

The aim of our study was to assess the association of common sequence variants, and selected interactions, with HDL-c plasma levels. We analysed 743 individuals (340 men and 403 women) with high mean triglyceride and LDL-c levels. The association of fivepolymorphic sites (ABCA1 g.1051G>A, APOA1 g.-75G>A, CETP g.-629C>A, HNF1A g.102A>C, and LIPG g.584C>T), apoE isoforms and selected interactions with HDL-c levels were evaluated using linear regression models. After adjusting for triglycerides, sex, andBMI the only genotype with a statistically significant effect on HDL-c levels (p-value=0.004) was the CETP promoter variant. Further, linear regression model with interactions included indicated possible interplay between APOA1 genotype and menopause (p-value=0.002) and ABCA1 and APOE isoforms (p-value=0.017) on HDL-c plasma concentration. Our study indicated that not only the CETP variant but also apoE isoforms and menopause could operate as potent modulators of HDL-c concentrations.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/NS10327" target="_blank" >NS10327: Complex genetic analysis of patients with mental retardation and dysmorphias - establisment of proper diagnostic procedure</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

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Volume of the periodical

43

Issue of the periodical within the volume

9

Country of publishing house

CA - CANADA

Number of pages

5

Pages from-to

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UT code for WoS article

000278161200009

EID of the result in the Scopus database

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