Decreased serum antioxidant capacity in patients with Wilson disease is associated with neurological symptoms

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F12%3A11394" target="_blank" >RIV/00064165:_____/12:11394 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/12:11394
Result on the web
<a href="http://dx.doi.org/10.1007/s10545-011-9422-5" target="_blank" >http://dx.doi.org/10.1007/s10545-011-9422-5</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Decreased serum antioxidant capacity in patients with Wilson disease is associated with neurological symptoms
Original language description
Wilson disease (WD) is an inherited disorder of copper disposition caused by an ATP7B transporter gene mutation, leading to copper accumulation in predisposed tissues. In addition to a genetic predisposition, other factors are likely to contribute to itsclinical manifestation. The aim of the study was to assess whether oxidative stress affects the phenotypic manifestation of WD. In 56 patients with WD (29 men; 26 with the hepatic form, 22 with the neurologic form, and eight asymptomatic; mean age 38.5+/- 12 years), total serum antioxidant capacity (TAC) and inflammatory parameters (hs-CRP, IL-1 beta, IL-2, IL-6, IL-10, and TNF-alpha) were analyzed and related to the clinical manifestation, and mutations of the ATP7B gene. The control group for the TAC and inflammatory parameters consisted of 50 age- and gender-matched healthy individuals. WD patients had a significantly lower TAC (p < 0.00001), lower IL-10 levels (p = 0.039), as well as both higher IL-1 beta (p = 0.019) and IL-6 (p =
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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