Tramadol efficacy in patients with postoperative pain in relation to CYP2D6 and MDR1 polymorphisms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F12%3A12599" target="_blank" >RIV/00064165:_____/12:12599 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/12:12599 RIV/00064203:_____/12:7994

Result on the web

<a href="http://dx.doi.org/10.4149/BLL_2012_036" target="_blank" >http://dx.doi.org/10.4149/BLL_2012_036</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Tramadol efficacy in patients with postoperative pain in relation to CYP2D6 and MDR1 polymorphisms

Original language description

The aim of our study was to evaluate impact of CYP2D6 and MDR1 polymorphisms on the analgesic efficacy of tramadol in patients after a knee arthroscopy. Pharmacokinetics of tramadol and its metabolites is stereoselective and displays high interindividualvariability correlating with polymorphic CYP2D6 in the population. Available data provide controversial results regarding the analgesic efficacy of tramadol in subjects with different CYP2D6 genotypes. METHODS: Pain intensity was assessed using visual analogue scale at 2 and 24 hours after the knee arthroscopy in 156 patients. Polymorphisms CYP2D6*3,*4,*5,*6, and gene duplication and C3435T in MDR1 gene were analyzed by PCR - RFLP. Results: Mean VAS2h value in the whole study group was 44.0 +/- 16.5 mm. Mean pain difference, was lowest in the UM group and highest in the PM group. The pain difference varied significantly among the CYP2D6 subgroups (F = 4.29; p = 0.006) with significant differences between homEM vs hetEM, homEM vs PM, an

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/GP305%2F08%2FP069" target="_blank" >GP305/08/P069: Pharmacogenetics analgetic efficacy of tramadol in acute pain treatment.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

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Volume of the periodical

113

Issue of the periodical within the volume

3

Country of publishing house

SK - SLOVAKIA

Number of pages

4

Pages from-to

152-155

UT code for WoS article

000302385900005

EID of the result in the Scopus database

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