Impact of MDR1 genetic polymorphisms on postoperative piritramide analgesia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10174174" target="_blank" >RIV/00216208:11110/13:10174174 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/13:10174174
Result on the web
<a href="http://dx.doi.org/10.4149/BLL_2013_029" target="_blank" >http://dx.doi.org/10.4149/BLL_2013_029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2013_029" target="_blank" >10.4149/BLL_2013_029</a>
Alternative languages
Result language
angličtina
Original language name
Impact of MDR1 genetic polymorphisms on postoperative piritramide analgesia
Original language description
Objectives: The aim of prospective study was to evaluate the therapeutic efficacy of piritramide in patients after removal of parathyroid glands in relation to MDR1 genotype. In the treatment of moderate acute postoperative pain, piritramide plays a major role. It is difficult to predict its optimal therapeutic efficacy and tolerability in individual patients. Methods: We compared the effect of piritramide in 56 patients after surgical removal of parathyroid glands in a prospective study. We evaluated pain intensity, pain difference and sum of pain difference (SPID) using visual analogue scale (VAS in mm) and adverse effects in the relationship with the MDR1 - polymorphism of G2677T/A. Results: In the wild-type group (2677GG), there was maximal pain difference of 30.6 +/- 24.9 and SPID of 209.33 +/- 95.80 while in genotype 2677TT and 2677GT, the corresponding values were 19.5 +/- 25.5 and 147.07 +/- 91.38, respectively. In group of patients with wild type of 2677GG genotype, there was
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislavske Lekarske Listy
ISSN
0006-9248
e-ISSN
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Volume of the periodical
114
Issue of the periodical within the volume
3
Country of publishing house
SK - SLOVAKIA
Number of pages
3
Pages from-to
133-135
UT code for WoS article
000315758300006
EID of the result in the Scopus database
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