Genetic variants in C-type lectin genes are associated with colorectal cancer susceptibility and clinical outcome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F13%3A10192847" target="_blank" >RIV/00064165:_____/13:10192847 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/13:00396305 RIV/00216208:11110/13:10192847
Result on the web
<a href="http://dx.doi.org/10.1002/ijc.28251" target="_blank" >http://dx.doi.org/10.1002/ijc.28251</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ijc.28251" target="_blank" >10.1002/ijc.28251</a>

Result language
angličtina
Original language name
Genetic variants in C-type lectin genes are associated with colorectal cancer susceptibility and clinical outcome
Original language description
Inflammatory responses play a vital role at different stages of colorectal carcinogenesis. C-type lectins mediate inflammatory/immune responses and participate in immune escape of pathogens and tumors. Our study aimed to evaluate the correlation betweenpolymorphisms in three C-type lectin genes, CD209, MBL2 and REG4, and colorectal cancer (CRC) risk and clinical outcome. We genotyped 15 potentially functional single nucleotide polymorphisms (SNPs) and assessed their associations with CRC risk in a case-control study of 1353 CRC cases and 767 healthy controls from the Czech Republic. We also analyzed these SNPs in relation to overall and event-free survival in 414 patients. Two CD209 SNPs were associated with CRC risk after adjustment for multiple comparison. Minor allele carriers of the promoter SNP rs2287886 had an increased risk of CRC (OR 1.30, 95% CI 1.08-1.56), while minor allele carriers of the 3UTR SNP, rs7248637, had a decreased risk (OR 0.74, 95% CI 0.60-0.91). Multivariate s
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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