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Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F08%3A00314379" target="_blank" >RIV/68378041:_____/08:00314379 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer

  • Original language description

    The common single nucleotide polymorphism (SNP) rs3802842 at 11q23.1 has recently been reported to be associated with risk of colorectal cancer (CRC). To examine this association in detail we genotyped rs3802842 in eight independent case-control series comprising a total of 10,638 cases and 10,457 healthy individuals. A significant association between the C allele of rs3802842 and CRC risk was found (per allele OR =1.17; 95% confidence interval [CI]: 1.12-1.22; P=1.08 x 10(-12)) with the risk allele more frequent in rectal than colonic disease (P=0.02).

  • Czech name

    Upřesnění vlivu 11q23.1 variace ve vztahu k riziku vzniku CRC

  • Czech description

    Jednonukleotidový polymorfizmus rs3802842 na 11q23.1 byl nedávno publikován jako asociovaný s rizikem vzniku CRC. Naším cílem bylo tuto asociaci prozkoumat do detailů v 8 různych case-control sériích sestávajících se ze 10,368 pacientů a 10,457 zdravýchjedinců. Zaznamenali jsme signifikantní asociaci mezi C alelou rs3802842 a rizikem vzniku CRC s vyšší frekvencí C alely v rektální části tlustého střeva v porovnání se samotným tlustým střevem.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA310%2F07%2F1430" target="_blank" >GA310/07/1430: Molecular and genetic characteristics of sporadic colorectal cancer in the Czech Republic.</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Human Molecular Genetics

  • ISSN

    0964-6906

  • e-ISSN

  • Volume of the periodical

    17

  • Issue of the periodical within the volume

    23

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

  • UT code for WoS article

    260980800010

  • EID of the result in the Scopus database