Inherited variability in a master regulator polymorphism (rs4846126) associates with survival in 5-FU treated colorectal cancer patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F14%3A10284435" target="_blank" >RIV/00064165:_____/14:10284435 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/14:00431922 RIV/00216208:11110/14:10284435
Result on the web
<a href="http://dx.doi.org/10.1016/j.mrfmmm.2014.05.007" target="_blank" >http://dx.doi.org/10.1016/j.mrfmmm.2014.05.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mrfmmm.2014.05.007" target="_blank" >10.1016/j.mrfmmm.2014.05.007</a>
Alternative languages
Result language
angličtina
Original language name
Inherited variability in a master regulator polymorphism (rs4846126) associates with survival in 5-FU treated colorectal cancer patients
Original language description
Background: Treatment with 5-fluorouracil (5-FU) is known to improve survival in many cancers including colorectal cancer. Response to the treatment, overall survival and recurrence show inter-individual variation. Methods: In this study we employed a strategy to search eQTL variants influencing the expression of a large number of genes. We identified four single nucleotide polymorphisms, defined as master regulators of transcription, and genotyped them in a set of 218 colorectal cancer patients undergoing adjuvant 5-FU based therapy. Results: Our results showed that the minor allele variant of the rs4846126 polymorphism was associated with poor overall and progression-free survival. Patients that were homozygous for the variant allele showed an over two fold increased risk of death (HR 2.20 95%CI 1.05-4.60) and progression (HR 2.88, 95% 1.47-5.63). The integration of external information from publicly available gene expression repositories suggested that the rs4846126 polymorphism des
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutation Research
ISSN
0027-5107
e-ISSN
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Volume of the periodical
766
Issue of the periodical within the volume
August
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
7-13
UT code for WoS article
000340321200002
EID of the result in the Scopus database
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