DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F08%3A00093935" target="_blank" >RIV/68378041:_____/08:00093935 - isvavai.cz</a>
Alternative codes found
RIV/75010330:_____/08:00007993 RIV/00216208:11110/08:1666 RIV/00064165:_____/08:1666
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic
Original language description
In the present study we investigated the role of nine single nucleotide polymorphisms in 8 DNA repair genes on the risk of colorectal cancer in a hospital-based case-control population (532 cases and 532 sex- and age-matched controls). Data analysis showed that the variant allele homozygotes for the Asn148Glu polymorphism in the APE1 gene were at a statistically non-significant increased risk of colorectal cancer. The risk was more pronounced for colon cancer (odds ratio; OR: 1.50, 95% confidence interval; CI 1.01-2.22; p=0.05). In smokers the polymorphism in hOGG1 showed increased risk of colorectal cancer The analysis of binary genotype combinations showed increased colorectal cancer risk in individuals simultaneously homozygous for the variant alleles of APE1 Asn148Glu and hOGG1 Ser326Cys (OR: 6.37, 95% CI 1.40-29.02; p=0.02).
Czech name
Polymorfismy genu DNA reparace a riziko kolorektalniho karcinomu v České
Czech description
V článku jsme sledovaly vliv 9 polymorfizmů v 8 genech DNA reparace ve vztahu k riziku vzniku CRC u 532 pacientů a 532 kontrolních skupin. Zjistili jsme statisticky nesignifikantní vliv genu APE1 na riziko vzniku CRC (OR: 1.50, 95% confidence interval; CI 1.01-2.22; p=0.05). Po stratifikaci věku jsme pozorovali zvýšené riziko vzniku CRC ve skupině lidí ve věku 64-86 u genu APE1. Kuřáci měli zvýšené riziko vzniku CRC v případě genu hOGG1 Ser326Cys. Binární kombinace genů APE1 Asn148Glu a hOGG1 Ser326Cyspoukazala na zvýšené riziko vzniku CRC. Vliv ostatních genů se neprokázal.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>R - Projekt Ramcoveho programu EK
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutation Research
ISSN
0027-5107
e-ISSN
—
Volume of the periodical
638
Issue of the periodical within the volume
1-2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
146-153
UT code for WoS article
—
EID of the result in the Scopus database
—