Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer??

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F08%3A%230000360" target="_blank" >RIV/65269705:_____/08:#0000360 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/08:3159 RIV/68378041:_____/08:00318750 RIV/00064165:_____/08:3159 RIV/75010330:_____/08:00007992

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer??

Original language description

The Czech Republic presents one of the highest incidences of colorectal cancer in the world. We genotyped 10 single nucleotide polymorphisms in five DNA mismatch repair genes in 614 colorectal cancer cases and 614 matched controls from this country. Thecarriers of T-allele of the hMSH6-556G > T polymorphism were at increased risk of colorectal cancer (OR 1.29; 95% CI 1.02?1.62). The stratification of data showed that risk associated with the polymorphism was confined to rectal cancer (OR 1.42; 95% CI 1.03?1.95). The A-allele of the Ex1 - 145G > A polymorphism in the hMSH6 gene was associated with a decreased risk of colorectal cancer (OR 0.76; 95% CI 0.60?0.98). The C-allele of the IVS4-101G > C polymorphism in hMSH6 was associated with an increased risk of colon cancer (OR 1.34; 95% CI 1.03?1.74).

Czech name

Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer?

Czech description

The Czech Republic presents one of the highest incidences of colorectal cancer in the world. We genotyped 10 single nucleotide polymorphisms in five DNA mismatch repair genes in 614 colorectal cancer cases and 614 matched controls from this country. Thecarriers of T-allele of the hMSH6-556G T polymorphism were at increased risk of colorectal cancer (OR 1.29; 95% CI 1.02?1.62). The stratification of data showed that risk associated with the polymorphism was confined to rectal cancer (OR 1.42; 95% CI 1.03?1.95). The A-allele of the Ex1 - 145G > A polymorphism in the hMSH6 gene was associated with a decreased risk of colorectal cancer (OR 0.76; 95% CI 0.60?0.98). The C-allele of the IVS4-101G > C polymorphism in hMSH6 was associated with an increased risk of colon cancer (OR 1.34; 95% CI 1.03?1.74).

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

<a href="/en/project/GA310%2F07%2F1430" target="_blank" >GA310/07/1430: Molecular and genetic characteristics of sporadic colorectal cancer in the Czech Republic.</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mutation Research

ISSN

0027-5107

e-ISSN

—

Volume of the periodical

648

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

—

UT code for WoS article

000261797000006

EID of the result in the Scopus database

—