Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer??
Result description
The Czech Republic presents one of the highest incidences of colorectal cancer in the world. We genotyped 10 single nucleotide polymorphisms in five DNA mismatch repair genes in 614 colorectal cancer cases and 614 matched controls from this country. Thecarriers of T-allele of the hMSH6-556G > T polymorphism were at increased risk of colorectal cancer (OR 1.29; 95% CI 1.02?1.62). The stratification of data showed that risk associated with the polymorphism was confined to rectal cancer (OR 1.42; 95% CI 1.03?1.95). The A-allele of the Ex1 - 145G > A polymorphism in the hMSH6 gene was associated with a decreased risk of colorectal cancer (OR 0.76; 95% CI 0.60?0.98). The C-allele of the IVS4-101G > C polymorphism in hMSH6 was associated with an increased risk of colon cancer (OR 1.34; 95% CI 1.03?1.74).
Keywords
The result's identifiers
Result code in IS VaVaI
Alternative codes found
RIV/00216208:11110/08:3159 RIV/68378041:_____/08:00318750 RIV/00064165:_____/08:3159 RIV/75010330:_____/08:00007992
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer??
Original language description
The Czech Republic presents one of the highest incidences of colorectal cancer in the world. We genotyped 10 single nucleotide polymorphisms in five DNA mismatch repair genes in 614 colorectal cancer cases and 614 matched controls from this country. Thecarriers of T-allele of the hMSH6-556G > T polymorphism were at increased risk of colorectal cancer (OR 1.29; 95% CI 1.02?1.62). The stratification of data showed that risk associated with the polymorphism was confined to rectal cancer (OR 1.42; 95% CI 1.03?1.95). The A-allele of the Ex1 - 145G > A polymorphism in the hMSH6 gene was associated with a decreased risk of colorectal cancer (OR 0.76; 95% CI 0.60?0.98). The C-allele of the IVS4-101G > C polymorphism in hMSH6 was associated with an increased risk of colon cancer (OR 1.34; 95% CI 1.03?1.74).
Czech name
Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer?
Czech description
The Czech Republic presents one of the highest incidences of colorectal cancer in the world. We genotyped 10 single nucleotide polymorphisms in five DNA mismatch repair genes in 614 colorectal cancer cases and 614 matched controls from this country. Thecarriers of T-allele of the hMSH6-556G T polymorphism were at increased risk of colorectal cancer (OR 1.29; 95% CI 1.02?1.62). The stratification of data showed that risk associated with the polymorphism was confined to rectal cancer (OR 1.42; 95% CI 1.03?1.95). The A-allele of the Ex1 - 145G > A polymorphism in the hMSH6 gene was associated with a decreased risk of colorectal cancer (OR 0.76; 95% CI 0.60?0.98). The C-allele of the IVS4-101G > C polymorphism in hMSH6 was associated with an increased risk of colon cancer (OR 1.34; 95% CI 1.03?1.74).
Classification
Type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutation Research
ISSN
0027-5107
e-ISSN
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Volume of the periodical
648
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
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UT code for WoS article
000261797000006
EID of the result in the Scopus database
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Basic information
Result type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP
FD - Oncology and haematology
Year of implementation
2008