Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in Czech Republic
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F09%3A00314441" target="_blank" >RIV/68378041:_____/09:00314441 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in Czech Republic
Original language description
To assess the role of genetic variants on the disease, we genotyped polymorphisms in the TP53 (rs17878362:A1>A2, rs1042522:G>C, rs12947788:C>T, and rs17884306:G>A), CDKN1A (rs1801270:C>A and rs1059234:C>T), and CDKN2A (rs3731249:G>A, rs11515:C>G, and rs3088440:C>T) genes in 614 hospital-based colorectal cancer cases and 614 matched controls from the country. The two most common haplotypes, A1GCG and A2CCG were present in 81% of the cases compared to 71% of the controls. In comparison to the most commonhaplotype (A1GCG), the haplotype A2CCG was associated with an increased risk (odds ratio OR 1.40, 95% confidence interval CI 1.07-1.82), while the four other haplotypes A1CCG (OR 0.60 95% CI 0.45-0.79), A2GCG (OR 0.53 95% CI 0.35-0.81), A1GTG (OR 0.31 95% CI 0.15-0.64), and A1GCA (OR 0.19 95% CI 0.07-0.51) were associated with a decreased risk. No association with the disease was observed with haplotypes of the CDKN1A and CDKN2A polymorphisms.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA310%2F07%2F1430" target="_blank" >GA310/07/1430: Molecular and genetic characteristics of sporadic colorectal cancer in the Czech Republic.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Human Mutation
ISSN
1059-7794
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
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UT code for WoS article
000265006400021
EID of the result in the Scopus database
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