Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F09%3A00001677" target="_blank" >RIV/00216208:11120/09:00001677 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/09:5980 RIV/75010330:_____/09:00008343

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in the Czech Republic

Original language description

The Czech Republic has one of the highest incidences of colorectal cancer (CRC) in the world. To assess the role of genetic variants on the disease, we genotyped polymorphisms in the TP53 (rs17878362: A(1)>A(2), rs1042522:G>C, rs12947788: C>T, and rs17884306:G>A), CDKN1A (rs1801270: C>A and rs1059234:C>T), and CDKN2A (rs3731249:G>A, rs11515:C>G, and rs3088440: C>T) genes in 614 hospital-based CRC cases and 614 matched controls from the country. Despite the tendency toward differential distribution of variant allele frequencies for some polymorphisms, none was significantly associated with CRC risk. We observed differential distribution of major haplotypes arising from four polymorphisms ill the TP53 gene between cases and controls (global P<0.0001). The two most common haplotypes, A(1)GCG and A(2)CCG, were present in 81% of the cases compared to 71% of the controls. In comparison to the most common haplotype (A(1)GCG), the haplotype A2CCG was associated with an increased

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA310%2F07%2F1430" target="_blank" >GA310/07/1430: Molecular and genetic characteristics of sporadic colorectal cancer in the Czech Republic.</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Human Mutation

ISSN

1059-7794

e-ISSN

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Volume of the periodical

30

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

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UT code for WoS article

000265006400021

EID of the result in the Scopus database

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