Genetic profile of genes involved in cell cycle control: The risk of sporadic colorectal cancer in the Czech Republic

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00385620" target="_blank" >RIV/68378041:_____/12:00385620 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Genetic profile of genes involved in cell cycle control: The risk of sporadic colorectal cancer in the Czech Republic
Original language description
The Czech Republic has one of the highest incidence rates of colorectal cancer (CRC) worldwide. In the present study, we genotyped common variants in cell cycle and DNA repair genes to assess the influence of genetic variation on the CRC risk, in 614 hospital-based CRC cases and 614 matched controls. Despite a tendency towards a differential distribution of the variant allele frequencies for some cell cycle polymorphisms, none was significantly associated with CRC risk. We observed a differential distribution between cases and controls of major haplotypes arising from the four analysed variants in the TP53 gene.
Czech name
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Czech description
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Project
<a href="/en/project/GA310%2F07%2F1430" target="_blank" >GA310/07/1430: Molecular and genetic characteristics of sporadic colorectal cancer in the Czech Republic.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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