MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F14%3A10292388" target="_blank" >RIV/00064165:_____/14:10292388 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/14:#0000481
Result on the web
<a href="http://dx.doi.org/10.1155/2014/508923" target="_blank" >http://dx.doi.org/10.1155/2014/508923</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/508923" target="_blank" >10.1155/2014/508923</a>

Result language
angličtina
Original language name
MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women
Original language description
The gene MTNR1B encodes a receptor for melatonin. Melatonin receptors are expressed in human beta-cells, which implies that genetic variants might affect glucose tolerance. Meta-analysis confirmed that the rs10830963 shows the most robust association. The aim of the study was to assess the rs10830963 in Czech GDM patients and controls and to study relations between the SNP and biochemical as well as anthropometric characteristics. Our cohort consisted of 880 women; 458 were diagnosed with GDM, and 422 were normoglycemic controls without history of GDM. Despite similar BMI, the GDM group showed higher WHR, waist circumference, abdominal circumference, and total body fat content. The risk allele G was more frequent in the GDM group (38.3 versus 29.4% incontrols, OR 1.49 CI95% [1.22; 1.82]; P-OR = 0.0001). In spite of higher frequency, the G allele in the GDM group was not associated with any markers of glucose metabolism. In contrast, controls showed significant association of the allel
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
<a href="/en/project/NT13544" target="_blank" >NT13544: Role of Genetic Variability in the Pathogenesis of Type 2 Diabetes Mellitus and Gestational Diabetes</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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