The prevalence of nonalcoholic liver steatosis in patients with type 2 diabetes mellitus in the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F15%3A10285526" target="_blank" >RIV/00064165:_____/15:10285526 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/15:10285526

Result on the web

<a href="http://biomed.papers.upol.cz/pdfs/bio/2015/03/18.pdf" target="_blank" >http://biomed.papers.upol.cz/pdfs/bio/2015/03/18.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2014.033" target="_blank" >10.5507/bp.2014.033</a>

Result language

angličtina

Original language name

The prevalence of nonalcoholic liver steatosis in patients with type 2 diabetes mellitus in the Czech Republic

Original language description

Nonalcoholic fatty liver disease (NAFLD) is associated with components of the metabolic syndrome (MS) but the prevalence of NAFLD in the Czech Republic is unknown. The aim of this study was to assess the latter in patients with type 2 diabetes (DM2) and to compare the noninvasive fibrosis scores with ultrasound findings in those patients. 180 consecutive patients with DM2 (mean age 64.2 +- 9.3 years, 63% men) were examined for liver biochemistry, MS parameters and had liver ultrasound. MS was diagnosed according to the International Diabetes Federation. The diagnosis of NAFLD was based on liver ultrasound. Other aetiology of liver lesion was ruled out. Additionally, AST/ALT ratio, APRI, NAFLD fibrosis score, FIB4 and BARD scores were calculated. 93% of patients met the MS criteria, 79 % had NAFLD and 13 % had ultrasound signs of fibrosis/cirrhosis. NAFLD patients had greater weight (96.9 +- 19.3 vs 84.7 +- 14.7 kg; P = 0.003), BMI (32.6 +- 5.2 vs 29.4 +- 5.4 kg/m2; P = 0.007), waist circumference (113.8 +- 12.8 vs 107.1 +- 10.3 cm; P = 0.033), ALT (0.73 +- 0.57 vs 0.55 +- 0.53 ukat/L, P = 0.007) and triglyc- eridaemia (1.9 +- 1.4 vs 1.4 +- 1 mmol/L; P = 0.005) than patients without NAFLD. There were no significant differences in age, sex, cholesterol, fasting glycaemia or glycated haemoglobin. Of calculated scores only the NAFLD fibrosis score revealed significant differences between patients with and without ultrasound signs of fibrosis/cirrhosis (1.027 +- 2.228 vs -0.118 +- 1.402, P = 0.026). Patients with DM2 had in the majority of cases NAFLD which was related to weight, BMI, waist circumfer-ence and serum triglycerides. The validity of the liver fibrosis scoring system has to be assessed in those patients in the future.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/NT11247" target="_blank" >NT11247: The role of protective mechanisms, oxidative stress and inflammatory reaction in the progreof liver damage in patient with metabolic syndrome and possible influence of antioxidative factors on the prevention of liver damage in experimental model of NASH.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Volume of the periodical

159

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

442-448

UT code for WoS article

000364948100018

EID of the result in the Scopus database

2-s2.0-84942856721