The diagnostic performance of cardiac magnetic resonance in detection of myocardial involvement in AL amyloidosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10295388" target="_blank" >RIV/00064165:_____/16:10295388 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10295388 RIV/00159816:_____/16:00068468
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/cpf.12216/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/cpf.12216/epdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/cpf.12216" target="_blank" >10.1111/cpf.12216</a>
Alternative languages
Result language
angličtina
Original language name
The diagnostic performance of cardiac magnetic resonance in detection of myocardial involvement in AL amyloidosis
Original language description
BACKGROUND: The non-invasive assessment of amyloid heart disease may be challenging. Cardiac magnetic resonance (CMR) represents a method of choice for assessment of left ventricular (LV) morphology and function, and it also provides a unique possibility to evaluate the presence of amyloid deposition by the late gadolinium enhancement (LGE) technique. However, so far, published studies have not been consistent in terms of described LGE patterns associated with amyloid cardiomyopathy. AIMS: To compare echocardiographic and CMR assessment of LV morphology and function and to evaluate the presence and pattern of LGE in a population of patients with AL amyloid cardiomyopathy. METHODS: Twenty-two consecutive patients with newly diagnosed AL amyloid cardiomyopathy and without contraindications to CMR were comprehensively examined by echocardiography and CMR. RESULTS: Echocardiography and CMR did not differ in the evaluation of interventricular septal thickness, LV end-diastolic diameter and ejection fraction. Significant differences were found between echocardiographic and CMR estimates of LV end-diastolic volume (P<0.01) and LV mass (P<0.001). Various global LGE patterns (transmural homogenous or heterogeneous, subendocardial) were present in 17 patients (77%), patchy LGE was observed in one case (4.5%) and suboptimal nulling of the myocardium was reported in two subjects (9%). CONCLUSIONS: Echocardiography significantly overestimates LV mass and underestimates LV volumes in patients with AL amyloid cardiomyopathy as compared to CMR. As it is present in more than three quarters of individuals with AL amyloid cardiomyopathy, any type of global LGE pattern may be considered as pathogenomic for amyloid heart disease.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
O - Projekt operacniho programu
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Physiology and Functional Imaging
ISSN
1475-0961
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
218-224
UT code for WoS article
000374345400007
EID of the result in the Scopus database
2-s2.0-84962821860