Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074211" target="_blank" >RIV/00159816:_____/21:00074211 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/21:00074211 RIV/00216224:14110/21:00121084

Result on the web

<a href="https://ojrd.biomedcentral.com/articles/10.1186/s13023-021-01704-9" target="_blank" >https://ojrd.biomedcentral.com/articles/10.1186/s13023-021-01704-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13023-021-01704-9" target="_blank" >10.1186/s13023-021-01704-9</a>

Result language

angličtina

Original language name

Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients

Original language description

BackgroundDuchenne muscular dystrophy (DMD) manifests in males mainly by skeletal muscle impairment, but also by cardiac dysfunction. The assessment of the early phases of cardiac involvement using echocardiography is often very difficult to perform in these patients. The aim of the study was to use cardiac magnetic resonance (CMR) strain analysis and mitral annular plane systolic excursion (MAPSE) in the detection of early left ventricular (LV) dysfunction in DMD patients. Methods and resultsIn total, 51 male DMD patients and 18 matched controls were examined by CMR. MAPSE measurement and functional analysis using feature tracking (FT) were performed. Three groups of patients were evaluated: A/ patients with LGE and LV EF&lt;50% (n=8), B/ patients with LGE and LVEF &gt;= 50% (n=13), and C/ patients without LGE and LVEF &gt;= 50% (n=30). MAPSE and global LV strains of the 3 DMD groups were compared to controls (n=18). Groups A and B had significantly reduced values of MAPSE, global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) in comparison to controls (p&lt;0.05). The values of MAPSE (11.61.9 v 13.7 +/- 2.7 mm) and GCS (- 26.2 +/- 4.2 v - 30.0 +/- 5.1%) were significantly reduced in group C compared to the controls (p&lt;0.05).Conclusion DMD patients had decreased LV systolic function measured by MAPSE and global LV strain even in the case of normal LV EF and the absence of LGE. FT and MAPSE measurement provide sensitive assessment of early cardiac involvement in DMD patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10603 - Genetics and heredity (medical genetics to be 3)

Project

<a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Orphanet Journal of Rare Diseases

ISSN

1750-1172

e-ISSN

—

Volume of the periodical

16

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

57

UT code for WoS article

000616474600005

EID of the result in the Scopus database

2-s2.0-85100173544