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Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074211" target="_blank" >RIV/00159816:_____/21:00074211 - isvavai.cz</a>

  • Alternative codes found

    RIV/65269705:_____/21:00074211 RIV/00216224:14110/21:00121084

  • Result on the web

    <a href="https://ojrd.biomedcentral.com/articles/10.1186/s13023-021-01704-9" target="_blank" >https://ojrd.biomedcentral.com/articles/10.1186/s13023-021-01704-9</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1186/s13023-021-01704-9" target="_blank" >10.1186/s13023-021-01704-9</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients

  • Original language description

    BackgroundDuchenne muscular dystrophy (DMD) manifests in males mainly by skeletal muscle impairment, but also by cardiac dysfunction. The assessment of the early phases of cardiac involvement using echocardiography is often very difficult to perform in these patients. The aim of the study was to use cardiac magnetic resonance (CMR) strain analysis and mitral annular plane systolic excursion (MAPSE) in the detection of early left ventricular (LV) dysfunction in DMD patients. Methods and resultsIn total, 51 male DMD patients and 18 matched controls were examined by CMR. MAPSE measurement and functional analysis using feature tracking (FT) were performed. Three groups of patients were evaluated: A/ patients with LGE and LV EF&lt;50% (n=8), B/ patients with LGE and LVEF &gt;= 50% (n=13), and C/ patients without LGE and LVEF &gt;= 50% (n=30). MAPSE and global LV strains of the 3 DMD groups were compared to controls (n=18). Groups A and B had significantly reduced values of MAPSE, global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) in comparison to controls (p&lt;0.05). The values of MAPSE (11.61.9 v 13.7 +/- 2.7 mm) and GCS (- 26.2 +/- 4.2 v - 30.0 +/- 5.1%) were significantly reduced in group C compared to the controls (p&lt;0.05).Conclusion DMD patients had decreased LV systolic function measured by MAPSE and global LV strain even in the case of normal LV EF and the absence of LGE. FT and MAPSE measurement provide sensitive assessment of early cardiac involvement in DMD patients.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10603 - Genetics and heredity (medical genetics to be 3)

Result continuities

  • Project

    <a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Orphanet Journal of Rare Diseases

  • ISSN

    1750-1172

  • e-ISSN

  • Volume of the periodical

    16

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

    57

  • UT code for WoS article

    000616474600005

  • EID of the result in the Scopus database

    2-s2.0-85100173544