Decreased Global Strains of LV in Asymptomatic Female Duchenne Muscular Dystrophy Gene Carriers Using CMR-FT

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075120" target="_blank" >RIV/00159816:_____/21:00075120 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/21:00120829

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S1936878X20308895?via%3Dihub#" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S1936878X20308895?via%3Dihub#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcmg.2020.09.016" target="_blank" >10.1016/j.jcmg.2020.09.016</a>

Result language

angličtina

Original language name

Decreased Global Strains of LV in Asymptomatic Female Duchenne Muscular Dystrophy Gene Carriers Using CMR-FT

Original language description

Duchenne muscular dystrophy (DMD) is the most common X-linked muscular dystrophy. Male patients can have DMD, whereas female patients can be asymptomatic carriers of DMD (aDMD-FC). They can develop cardiomyopathy, probably due to myocardial fibrosis. Early detection of functional myocardial dysfunction is critical for their prognosis. Using CMR-FT, this prospective study aimed to assess aDMD carriers&apos; left ventricular (LV) systolic function. We enrolled 37 aDMD and 20 healthy controls. We measured their global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), end-systolic (ESV), and end-diastolic (EDV) LV volumes and ejection fraction (EF) LV. aDMD and controls did not significantly differ in basic demographic data (age: 39.5 +- 9.1 vs 39.1 +- 10.7 years). There were found statistically significant differences in EF LV (56 +- 5 vs. 60 +- 3%), and all strain parameters (GLS (-19.4 +- 2.4 vs. -22.3 +- 2.2%), GCS (26.8 +- 3.3 vs. 29.5 +- 2.0%) and GRS (59.8 +- 12.9 vs. 70.9 +- 14.8%), all p&lt;0.05). aDMD carriers had significantly lower values of all strains than controls using CMR-FT, although they showed preserved EF LV. CMR-FT could benefit the early diagnosis of developing heart disease in asymptomatic patients with a DMD genetic predisposition.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JACC-Cardiovascular Imaging

ISSN

1936-878X

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

3

Pages from-to

1070-1072

UT code for WoS article

000647194600023

EID of the result in the Scopus database

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