Titin antibodies in "seronegative" myasthenia gravis - A new role for an old antigen
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10323037" target="_blank" >RIV/00064165:_____/16:10323037 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10323037
Result on the web
<a href="http://dx.doi.org/10.1016/j.jneuroim.2016.01.018" target="_blank" >http://dx.doi.org/10.1016/j.jneuroim.2016.01.018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jneuroim.2016.01.018" target="_blank" >10.1016/j.jneuroim.2016.01.018</a>
Alternative languages
Result language
angličtina
Original language name
Titin antibodies in "seronegative" myasthenia gravis - A new role for an old antigen
Original language description
Myasthenia gravis (MG) is an autoimmune disease caused by antibodies targeting the neuromuscular junction of skeletal muscles. Triple-seronegative MG (tSN-MG, without detectable AChR, MuSK and LRP4 antibodies), which accounts for similar to 10% of MG patients, presents a serious gap in MG diagnosis and complicates differential diagnosis of similar disorders. Several AChR antibody positive patients (AChR-MG) also have antibodies against titin, usually detected by ELISA. We have developed a very sensitive radioimmunoprecipitation assay (RIPA) for titin antibodies, by which many previously negative samples were found positive, including several from tSN-MG patients. The validity of the RIPA results was confirmed by western blots. Using this RIPA we screened 667 MG sera from 13 countries; as expected, AChR-MG patients had the highest frequency of titin antibodies (40.9%), while MuSK-MG and LRP4-MG patients were positive in 14.6% and 16.4% respectively. Most importantly, 13.4% (50/372) of the tSN-MG patients were also titin antibody positive. None of the 121 healthy controls or the 90 myopathy patients, and only 3.6% (7/193) of other neurological disease patients were positive. We thus propose that the present titin antibody RIPA is a useful tool for serological MG diagnosis of tSN patients.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroimmunology
ISSN
0165-5728
e-ISSN
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Volume of the periodical
292
Issue of the periodical within the volume
March
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
108-115
UT code for WoS article
000372561600017
EID of the result in the Scopus database
2-s2.0-84960910874