MuSK autoantibodies in myasthenia gravis detected by cell based assay - A multinational study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295622" target="_blank" >RIV/00216208:11110/15:10295622 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10295622
Result on the web
<a href="http://dx.doi.org/10.1016/j.jneuroim.2015.04.015" target="_blank" >http://dx.doi.org/10.1016/j.jneuroim.2015.04.015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jneuroim.2015.04.015" target="_blank" >10.1016/j.jneuroim.2015.04.015</a>

Result language
angličtina
Original language name
MuSK autoantibodies in myasthenia gravis detected by cell based assay - A multinational study
Original language description
Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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