Comparison of transcranial sonography-magnetic resonance fusion imaging in Wilson's and early-onset Parkinson's diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10324212" target="_blank" >RIV/00064165:_____/16:10324212 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10324212 RIV/61989592:15120/16:33159188

Result on the web

<a href="http://dx.doi.org/10.1016/j.parkreldis.2016.04.031" target="_blank" >http://dx.doi.org/10.1016/j.parkreldis.2016.04.031</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.parkreldis.2016.04.031" target="_blank" >10.1016/j.parkreldis.2016.04.031</a>

Result language

angličtina

Original language name

Comparison of transcranial sonography-magnetic resonance fusion imaging in Wilson's and early-onset Parkinson's diseases

Original language description

Introduction: Wilson's disease (WD) is a hereditary disorder caused by ATP7B mutations resulting in systemic copper accumulation. WD may manifest as early-adulthood parkinsonism; and atypical cases may be difficult to distinguish from early-onset Parkinson's disease (EO-PD), a neurodegenerative disorder with onset LESS-THAN OR EQUAL TO40 years of age. The aim of our study was to compare transcranial sonography (TCS)-magnetic resonance fusion imaging in WD and EO-PD and examine whether TCS can provide clinically useful information. Methods: We examined 22 WD, 16 EO-PD, and 24 healthy control subjects. We measured echogenicity and determined presence of MRI signal changes in T2-weighted images in the substantia nigra (SN) and lentiform nucleus (NL). TCS with the capability of magnetic resonance fusion and Virtual Navigator was used. The echogenicity indices of SN and NL were processed using digital image analysis to eliminate subjective evaluation errors. Results: Mean SN echogenicity index in EO-PD (39.8 +- 5.9 [SD]) was higher compared to WD (28.0 +- 4.6, p < 0.0001) and control subjects (28.8 +- 4.9, p < 0.0001). Mean NL echogenicity index was higher in WD (117.5 +- 37.0) compared to EO-PD (61.6 +- 5.4, p < 0.0001) and control subjects (54.9 +- 11.2, p < 0.0001). The SN hyperechogenicity had sensitivity 93.8%, and specificity 90.9%, while the NL hyperechogenicity had sensitivity 95.5% and specificity 93.8% for differentiation of WD and EO-PD. NL hyperechogenicity was more pronounced in WD subjects with putaminal MRI T2 hyperintensity (p < 0.05) but was also present in subjects without MRI abnormality. Conclusions: There are distinct TCS findings in WD and EO-PD complementary to MRI that can be utilized as highly sensitive and specific biomarkers of these disorders.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NV15-25602A" target="_blank" >NV15-25602A: Biomarkers of progression and treatment response in neurodegenerative disorders</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Parkinsonism and Related Disorders

ISSN

1353-8020

e-ISSN

—

Volume of the periodical

28

Issue of the periodical within the volume

July

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

87-93

UT code for WoS article

000379705500014

EID of the result in the Scopus database

2-s2.0-84964577492