Echogenicity of brain structures in Huntington ´s disease patients evaluated by transcranial sonography - magnetic resonance fusion imaging using virtual navigator and digital image analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F23%3AE0110574" target="_blank" >RIV/00843989:_____/23:E0110574 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/23:00079130 RIV/00216224:14110/23:00131198 RIV/61988987:17110/23:A2402L3N RIV/00216208:11110/23:10466013
Result on the web
<a href="https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2081-1635" target="_blank" >https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2081-1635</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1055/a-2081-1635" target="_blank" >10.1055/a-2081-1635</a>
Alternative languages
Result language
angličtina
Original language name
Echogenicity of brain structures in Huntington ´s disease patients evaluated by transcranial sonography - magnetic resonance fusion imaging using virtual navigator and digital image analysis
Original language description
Purpose: Transcranial sonography (TCS) magnetic resonance (MR) fusion imaging and digital image analysis are useful tools for the evaluation of various brain pathologies. This study aimed to compare the echogenicity of predefined brain structures in Huntington's disease (HD) patients and healthy controls by TCS-MR fusion imaging using Virtual Navigator and digitized image analysis. Materials and methods: The echogenicity of the caudate nucleus (CN), substantia nigra (SN), lentiform nucleus (LN), insula, and brainstem raphe (BR) evaluated by TCS-MR fusion imaging using digitized image analysis was compared between 21 HD patients and 23 healthy controls. The cutoff values of echogenicity indices for the CN, LN, insula, and BR with optimal sensitivity and specificity were calculated using receiver operating characteristic analysis. Results: The mean echogenicity indices for the CN (67.0±22.6 vs. 37.9±7.6, p<0.0001), LN (110.7±23.6 vs. 59.7±11.1, p<0.0001), and insula (121.7±39.1 vs. 70.8±23.0, p<0.0001) were significantly higher in HD patients than in healthy controls. In contrast, BR echogenicity (24.8±5.3 vs. 30.1±5.3, p<0.001) was lower in HD patients than in healthy controls. The area under the curve was 90.9%, 95.5%, 84.1%, and 81.8% for the CN, LN, insula, and BR, respectively. The sensitivity and specificity were 86% and 96%, respectively, for the CN and 90% and 100%, respectively, for the LN. Conclusion: Increased CN, LN, and insula echogenicity and decreased BR echogenicity are typical findings in HD patients. The high sensitivity and specificity of the CN and LN hyperechogenicity in TCS-MR fusion imaging make them promising diagnostic markers for HD.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Ultraschall in der Medizin
ISSN
0172-4614
e-ISSN
1438-8782
Volume of the periodical
44
Issue of the periodical within the volume
5
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
495-502
UT code for WoS article
000992933900001
EID of the result in the Scopus database
2-s2.0-85190320355