Serum microRNA-196 and microRNA-200 in pancreatic ductal adenocarcinoma of patients with diabetes mellitus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10325104" target="_blank" >RIV/00064165:_____/16:10325104 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10325104 RIV/00216208:11120/16:43911754 RIV/00064173:_____/16:N0000166 RIV/61383082:_____/16:00000201
Result on the web
<a href="http://dx.doi.org/10.1016/j.pan.2016.05.005" target="_blank" >http://dx.doi.org/10.1016/j.pan.2016.05.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pan.2016.05.005" target="_blank" >10.1016/j.pan.2016.05.005</a>

Result language
angličtina
Original language name
Serum microRNA-196 and microRNA-200 in pancreatic ductal adenocarcinoma of patients with diabetes mellitus
Original language description
Background/Objectives: Our aim was to compare expressions of 6 microRNAs (miRNAs) in patients with pancreatic ductal adenocarcinoma (PAC) and non-cancer patients, moreover according to the presence or absence of diabetes mellitus. Methods: Expressions of miRNA-192, -196, -200, -21, -30 and -423 were measured in 77 patients with PAC and 64 non-cancer patients (34 patients with type 2 DM and 30 control persons). 60 patients with PAC (78%) had DM or prediabetes and it was of new-onset (less than 2 years before the cancer diagnosis) in 44 out of them. Results: The expressions of all microRNAs were 1.4-3.7 times higher (significantly) in the PAC group compared to non-cancer patients. No difference was found between PAC diabetic and PAC non-diabetic patients. MicroRNA-200 was significantly higher in PAC patients with significant body weight loss against those without weight loss. Adding miRNA-196 and -200 to the current marker CA 19-9 improved the discriminative ability of the test (compared to CA 19-9 alone). Conclusion: MicroRNA-196 and -200 could be used as additional markers in PAC diagnosis.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Project
<a href="/en/project/NT14254" target="_blank" >NT14254: Early Diagnosis of Pancreatic Adenocarcinoma: Surface Proteases and Specific Biomarkers</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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